ArticleMolecular and cellular biology1994
Identification and characterization of Drosophila relatives of the yeast transcriptional activator SNF2/SWI2.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
80 citing papers in PubMed, 201 citations in OpenAlex.
- The roles of chromatin remodeling and 3D genome organization in cancers: from mechanistic insights to emerging treatment options.Molecular cancer · 2026Review
- Epigenetic regulation by DNA methylation, histone modifications and chromatin remodeling complexes in controlling spermatogenesis and their dysfunction with male infertility.Cellular and molecular life sciences : CMLS · 2025Review
- Arid1a regulates bladder urothelium formation and maintenance.Developmental biology · 2022Article
- H3K36 methylation and DNA-binding both promote Ioc4 recruitment and Isw1b remodeler function.Nucleic acids research · 2022Article
- BAZ1B the Protean Protein.Genes · 2021Review
- Mammalian SWI/SNF Chromatin Remodeling Complexes in Embryonic Stem Cells: Regulating the Balance Between Pluripotency and Differentiation.Frontiers in cell and developmental biology · 2020Review
- Chromatin regulation and dynamics in stem cells.Current topics in developmental biology · 2020Review
- The BAF complex in development and disease.Epigenetics & chromatin · 2019Review
- The SWI/SNF chromatin-remodeling factors BAF60a, b, and c in nutrient signaling and metabolic control.Protein & cell · 2018Review
- A simple and versatile system for the ATP-dependent assembly of chromatin.The Journal of biological chemistry · 2017Article
- Polycomb and trithorax opposition in development and disease.Wiley interdisciplinary reviews. Developmental biology · 2016Review
- SWI/SNF-directed stem cell lineage specification: dynamic composition regulates specific stages of skeletal myogenesis.Cellular and molecular life sciences : CMLS · 2016Review
- Chromatin remodelers: We are the drivers!!Nucleus (Austin, Tex.) · 2016Review
- Mutations of Chromatin Structure Regulating Genes in Human Malignancies.Current protein & peptide science · 2016Review
- Review
- The role of BAF (mSWI/SNF) complexes in mammalian neural development.American journal of medical genetics. Part C, Seminars in medical genetics · 2014Article
- Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation.Nature communications · 2014Article
- Nucleosome remodeling and epigenetics.Cold Spring Harbor perspectives in biology · 2013Review
- Chromatin remodeling in cancer: a gateway to regulate gene transcription.Molecular oncology · 2012Review
- Chromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange.Nature structural & molecular biology · 2012Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The Drosophila brahma (brm) gene encodes an activator of homeotic genes that is highly related to the yeast transcriptional activator SWI2 (SNF2), a potential helicase. To determine whether brm is a functional homolog of SWI2 or merely a member of a family of SWI2-related genes, we searched for additional Drosophila genes related to SWI2 and examined their function in yeast cells. In addition to brm, we identified one other Drosophila relative of SWI2: the closely related ISWI gene. The 1,027-residue ISWI protein contains the DNA-dependent ATPase domain characteristic of the SWI2 protein family but lacks the three other domains common to brm and SWI2. In contrast, the ISWI protein is highly related (70% identical) to the human hSNF2L protein over its entire length, suggesting that they may be functional homologs. The DNA-dependent ATPase domains of brm and SWI2, but not ISWI, are functionally interchangeable; a chimeric SWI2-brm protein partially rescued the slow growth of swi2- cells and supported transcriptional activation mediated by the glucocorticoid receptor in vivo in yeast cells. These findings indicate that brm is the closest Drosophila relative of SWI2 and suggest that brm and SWI2 play similar roles in transcriptional activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.