ArticleExperimental brain research1993
Increased proportion of acetylcholinesterase-rich zones and improved morphological integration in host striatum of fetal grafts derived from the lateral but not the medial ganglionic eminence.
Article in Experimental brain research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Neuronal Replacement as a Tool for Basal Ganglia Circuitry Repair: 40 Years in Perspective.Frontiers in cellular neuroscience · 2020Review
- Can manipulation of differentiation conditions eliminate proliferative cells from a population of ES cell-derived forebrain cells?Neurogenesis (Austin, Tex.) · 2016Article
- Interneurons from embryonic development to cell-based therapy.Science (New York, N.Y.) · 2014Review
- Differentiation of pluripotent stem cells into striatal projection neurons: a pure MSN fate may not be sufficient.Frontiers in cellular neuroscience · 2014Review
- Human pluripotent stem cell therapy for Huntington's disease: technical, immunological, and safety challenges human pluripotent stem cell therapy for Huntington's disease: technical, immunological, and safety challenges.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2011Article
- Cellular therapy and induced neuronal replacement for Huntington's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2011Review
- Origin and molecular specification of globus pallidus neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Amygdalar GABAergic-rich neural grafts attenuate anxiety-like behavior in rats.Behavioural brain research · 2009Article
- Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- The amygdaloid complex and the medial and lateral ventricular eminences in staged human embryos.Journal of anatomy · 2006Article
- Gene therapy in clinical medicine.Postgraduate medical journal · 2004Review
- Cell therapy in Huntington's disease.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics · 2004Review
- Neural transplantation in patients with Huntington's disease.CNS drugs · 2003Review
- Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Drugs of abuse and immediate-early genes in the forebrain.Molecular neurobiology · 1998Review
- Dopaminergic innervation of striatal grafts placed into different sites of normal striatum: differences in the tyrosine hydroxylase immunoreactive growth pattern.Experimental brain research · 1997Article
- Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres.Nature medicine · 1995Article
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4 authors.
Funding
Abstract
Fetal striatal grafts are found to have a modular organization revealed by acetylcholinesterase (AChE) histochemistry. The AChE-rich zones represent the only portions of these grafts that are anatomically and functionally integrated into the host brain. In this study, the medial and lateral ganglionic eminences (MGEs and LGEs) were selectively dissected from the basal telencephalon of embryonic-day-14 (E14) rat fetuses to compare their relative contributions to the AChE-rich fraction of intrastriatal grafts. Separate cell suspensions prepared from either eminence were stereotaxically implanted into excitotoxically lesioned neostriatum of adult rats. Eight weeks after transplantation, grafts of the MGE were compared with those of the LGE with respect to the proportion of AChE-rich zones, graft size, graft morphology, and afferent dopaminergic innervation as revealed by tyrosine hydroxylase (TH) immunostaining. The mean AChE-rich fraction in LGE grafts (87% +/- 4%) was markedly greater than the AChE-rich fraction in MGE grafts (25% +/- 10%). The LGE grafts were also morphologically better incorporated into the lesioned host striatum, partially reconstituting the striatal morphology. There was no statistically significant difference in graft size between the two groups. The AChE-rich LGE grafts were TH immunoreactive, whereas the AChE-poor MGE grafts were not. We conclude that grafts derived exclusively from the fetal LGE reconstitute the striatal morphology and consist almost entirely of AChE-rich zones.
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