ArticleThe EMBO journal1994
Setting limits on homeotic gene function: restraint of Sex combs reduced activity by teashirt and other homeotic genes.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 121 citations in OpenAlex.
- The Drosophila larval salivary gland, a simple and elegant model system to understand secretory organ development and function.Current opinion in insect science · 2026Review
- Supracellular actomyosin assemblies: master coordinators of development.Development (Cambridge, England) · 2025Review
- Single-cell analysis of the early Drosophila salivary gland reveals that morphogenetic control involves both the induction and exclusion of gene expression programs.PLoS biology · 2025Article
- Organogenetic transcriptomes of the Drosophila embryo at single cell resolution.Development (Cambridge, England) · 2024Article
- Transcription factor paralogs orchestrate alternative gene regulatory networks by context-dependent cooperation with multiple cofactors.Nature communications · 2022Article
- Ribbon boosts ribosomal protein gene expression to coordinate organ form and function.The Journal of cell biology · 2022Article
- Panarthropod tiptop/teashirt and spalt orthologs and their potential role as "trunk"-selector genes.EvoDevo · 2021Article
- Secrets of secretion-How studies of the Drosophila salivary gland have informed our understanding of the cellular networks underlying secretory organ form and function.Current topics in developmental biology · 2021Article
- Anterior Hox Genes and the Process of Cephalization.Frontiers in cell and developmental biology · 2021Review
- Article
- Cell-Autonomous and Non-cell-autonomous Function of Hox Genes Specify Segmental Neuroblast Identity in the Gnathal Region of the Embryonic CNS in Drosophila.PLoS genetics · 2016Article
- teashirt is required for head-versus-tail regeneration polarity in planarians.Development (Cambridge, England) · 2015Article
- Developmental competence and the induction of ectopic proboscises in Drosophila melanogaster.Development genes and evolution · 2013Article
- Organ-specific gene expression: the bHLH protein Sage provides tissue specificity to Drosophila FoxA.Development (Cambridge, England) · 2013Article
- Org-1 is required for the diversification of circular visceral muscle founder cells and normal midgut morphogenesis.Developmental biology · 2013Article
- The tiptop/teashirt genes regulate cell differentiation and renal physiology in Drosophila.Development (Cambridge, England) · 2013Article
- Homeotic functions of the Teashirt transcription factor during adult Drosophila development.Biology open · 2013Article
- Hox targets and cellular functions.Scientifica · 2013Article
- Anisotropy of Crumbs and aPKC drives myosin cable assembly during tube formation.Developmental cell · 2012Article
- Drosophila as a model for epithelial tube formation.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Each of the homeotic genes of the HOM or HOX complexes is expressed in a limited domain along the anterior-posterior axis. Each homeotic protein directs the formation of characteristic structures, such as wings or ribs. In flies, when a heat shock-inducible homeotic gene is used to produce a homeotic protein in all cells of the embryo, only some cells respond by altering their fates. We have identified genes that limit where the homeotic gene Sex combs reduced (Scr) can affect cell fates in the Drosophila embryo. In the abdominal cuticle Scr is prevented from inducing prothoracic structures by the three bithorax complex (BX-C) homeotic genes. However, two of the BX-C homeotic genes, Ultrabithorax (Ubx) and abdominal-A (abd-A), have no effect on the ability of Scr to direct the formation of salivary glands. Instead, salivary gland induction by Scr is limited in the trunk by the homeotic gene teashirt (tsh) and in the last abdominal segment by the third BX-C gene, Abdominal-B (AbdB). Therefore, spatial restrictions on homeotic gene activity differ between tissues and result both from the regulation of homeotic gene transcription and from restraints on where homeotic proteins can function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.