ArticleThe Journal of cell biology1994
Endocytosis occurs independently of annexin VI in human A431 cells.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 76 citations in OpenAlex.
- Revisiting the role of Annexins in membrane trafficking.Cellular and molecular life sciences : CMLS · 2025Review
- Annexins-a family of proteins with distinctive tastes for cell signaling and membrane dynamics.Nature communications · 2024Review
- Cargo regulates clathrin-coated pit invagination via clathrin light chain phosphorylation.The Journal of cell biology · 2018Article
- Annexin A6-A multifunctional scaffold in cell motility.Cell adhesion & migration · 2017Review
- Article
- Human annexin A6 interacts with influenza a virus protein M2 and negatively modulates infection.Journal of virology · 2012Article
- Article
- Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function.Molecular biology of the cell · 2011Article
- Differential Regulation of RasGAPs in Cancer.Genes & cancer · 2011Article
- Annexin A6 inhibits Ras signalling in breast cancer cells.Oncogene · 2009Article
- Annexin A6-induced alterations in cholesterol transport and caveolin export from the Golgi complex.Traffic (Copenhagen, Denmark) · 2007Article
- Clathrin promotes incorporation of cargo into coated pits by activation of the AP2 adaptor micro2 kinase.The Journal of cell biology · 2003Article
- The role of dynamin and its binding partners in coated pit invagination and scission.The Journal of cell biology · 2001Article
- Immunological development and cardiovascular function are normal in annexin VI null mutant mice.Molecular and cellular biology · 1999Article
- Annexin VI-mediated loss of spectrin during coated pit budding is coupled to delivery of LDL to lysosomes.The Journal of cell biology · 1998Article
- Functional analysis of the human annexin I and VI gene promoters.The Biochemical journal · 1998Article
- Functional implications of nitric oxide produced by mitochondria in mitochondrial metabolism.The Biochemical journal · 1998Article
- The association of annexin I with early endosomes is regulated by Ca2+ and requires an intact N-terminal domain.Molecular biology of the cell · 1996Article
- Annexin VI has tumour-suppressor activity in human A431 squamous epithelial carcinoma cells.British journal of cancer · 1995Article
- Annexin XIIIb: a novel epithelial specific annexin is implicated in vesicular traffic to the apical plasma membrane.The Journal of cell biology · 1995Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Annexin VI is one of a family of calcium-dependent phospholipid-binding proteins. Although the function of this protein is not known, various physiological roles have been proposed, including a role in the budding of clathrin-coated pits (Lin et al., 1992. Cell. 70:283-291.). In this study we have investigated a possible endocytotic role for annexin VI in intact cells, using the human squamous carcinoma cell line A431, and report that these cells do not express endogenous annexin VI, as judged by Western and Northern blotting and PCR/Southern blotting. To examine whether endocytosis might in some way be either facilitated or inhibited by the presence of annexin VI, a series of A431 clones were isolated in which annexin VI expression was achieved by stable transfection. These cells expressed annexin VI at similar levels to other human cell types. Using assays for endocytosis and recycling of the transferrin receptor, we report that each of these cellular processes occurs with identical kinetics in both transfected and wild-type A431 cells. In addition, purified annexin VI failed to support the scission of coated pits in permeabilized A431 cells. We conclude that annexin VI is not an essential component of the endocytic pathway, and that in A431 cells, annexin VI fails to exert any influence on internalization and recycling of the transferrin receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.