ArticleNaunyn-Schmiedeberg's archives of pharmacology1993
Neural ATP release and its alpha 2-adrenoceptor-mediated modulation in guinea-pig vas deferens.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 68 citations in OpenAlex.
- Physiological and pharmacological aspects of the vas deferens-an update.Frontiers in pharmacology · 2013Article
- Neuronal and non-neuronal modulation of sympathetic neurovascular transmission.Acta physiologica (Oxford, England) · 2011Review
- Antioxidant treatment restores prejunctional regulation of purinergic transmission in mesenteric arteries of deoxycorticosterone acetate-salt hypertensive rats.Neuroscience · 2010Article
- Selective modulation of noradrenaline release by alpha 2-adrenoceptor blockade in the rat-tail artery in vitro.British journal of pharmacology · 2004Article
- Effects of omega-conotoxin GVIA and diltiazem on double peaked vasoconstrictor responses to periarterial electric nerve stimulation in isolated canine splenic artery.British journal of pharmacology · 2000Article
- Electrochemical and electrophysiological characterization of neurotransmitter release from sympathetic nerves supplying rat mesenteric arteries.British journal of pharmacology · 1999Article
- P2-purinoceptor antagonists: I. Blockade of P2-purinoceptor subtypes and ecto-nucleotidases by small aromatic isothiocyanato-sulphonates.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Inhibition of purinergic transmission by prostaglandin E1 and E2 in the guinea-pig vas deferens: an electrophysiological study.British journal of pharmacology · 1996Article
- Opposite modulation of noradrenaline and ATP release in guinea-pig vas deferens through prejunctional beta-adrenoceptors: evidence for the beta 2 subtype.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Evaluation of P2-purinoceptor antagonists at two relaxation-mediating P2-purinoceptors in guinea-pig taenia coli.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Failure of tyramine to release neuronal ATP as a cotransmitter of noradrenaline in the guinea-pig vas deferens.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Opposite modulation of cotransmitter release in guinea-pig vas deferens: increase of noradrenaline and decrease of ATP release by activation of prejunctional beta-adrenoceptors.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Reactive red 2: a P2y-selective purinoceptor antagonist and an inhibitor of ecto-nucleotidase.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Comparison of corelease of noradrenaline and ATP evoked by hypogastric nerve stimulation and field stimulation in guinea-pig vas deferens.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Functional consequences of inhibition of nucleotide breakdown in rat vas deferens: a study with Evans blue.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Electrically-evoked release of taurine in the rat vas deferens: evidence for a purinoceptor-mediated effect.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Modulation of neural noradrenaline and ATP release by angiotensin II and prostaglandin E2 in guinea-pig vas deferens.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
- The fade of the purinergic neurogenic contraction of the guinea-pig vas deferens: analysis of possible mechanisms.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
- Release of ATP in rat vas deferens: origin and role of calcium.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
- Corelease of noradrenaline and ATP by brief pulse trains in guinea-pig vas deferens.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contractions, release of previously stored [3H]-noradrenaline (measured as overflow of total tritiated compounds) and release of ATP elicited by electrical field stimulation (210 pulses, 7 Hz) were studied in the superfused vas deferens of the guinea pig. Prazosin and suramin were used to suppress non-neural ATP release, and effects of bromoxidine and rauwolscine on the neural release thus isolated were examined. Electrical stimulation elicited reproducible contraction, tritium overflow and ATP overflow. Both prazosin (0.03-3 microM) and suramin (30-300 microM) reduced contractions as well as the evoked overflow of ATP. No visible contraction remained in 21 of 28 tissues exposed to prazosin 0.3 microM combined with suramin 300 microM. The evoked overflow of ATP under these conditions was about 17% of that observed in the absence of drugs. In the presence of prazosin 0.3 microM and suramin 300 microM, bromoxidine (0.01-1 microM) decreased and rauwolscine (0.1-10 microM) increased the evoked overflow of both tritium and ATP. Rauwolscine increased the evoked overflow of tritium to a significantly greater extent than the overflow of ATP. It is concluded that the overflow of ATP elicited by electrical (neural) stimulation in the presence of prazosin 0.3 microM and suramin 300 microM reflects purely neural release of ATP. This release of ATP, like the release of noradrenaline, is modulated through prejunctional alpha 2-adrenoceptors. The alpha 2-adrenoceptor modulation of the release of noradrenaline seems to be more marked than the modulation of the release of ATP.
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