ArticleJournal of clinical microbiology1993
Candida albicans genotyping in studies with patients with AIDS developing resistance to fluconazole.
Article in Journal of clinical microbiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 116 citations in OpenAlex.
- Random amplification of polymorphic DNA and microsatellite genotyping of pre- and posttreatment isolates of Candida spp. from human immunodeficiency virus-infected patients on different fluconazole regimens.Journal of clinical microbiology · 1998Trial
- Fluconazole concentrations in saliva from AIDS patients with oropharyngeal candidosis refractory to treatment with fluconazole.Antimicrobial agents and chemotherapy · 1995Trial
- Fluconazole resistance amongFrontiers in fungal biology · 2025Article
- Species diversity of yeast in oral colonization of insulin-treated diabetes mellitus patients.Mycopathologia · 2006Article
- Antifungal effects of lysozyme and lactoferrin against genetically similar, sequential Candida albicans isolates from a human immunodeficiency virus-infected southern Chinese cohort.Journal of clinical microbiology · 2001Article
- Emergence of resistance of Candida albicans to clotrimazole in human immunodeficiency virus-infected children: in vitro and clinical correlations.Journal of clinical microbiology · 2000Article
- The ins and outs of DNA fingerprinting the infectious fungi.Clinical microbiology reviews · 2000Review
- Specific chromosome alterations in fluconazole-resistant mutants of Candida albicans.Journal of bacteriology · 1999Article
- High aspartyl proteinase production and vaginitis in human immunodeficiency virus-infected women.Journal of clinical microbiology · 1999Article
- Clinical, cellular, and molecular factors that contribute to antifungal drug resistance.Clinical microbiology reviews · 1998Review
- Antifungal resistance trends towards the year 2000. Implications for therapy and new approaches.Drugs · 1997Review
- Parity among the randomly amplified polymorphic DNA method, multilocus enzyme electrophoresis, and Southern blot hybridization with the moderately repetitive DNA probe Ca3 for fingerprinting Candida albicans.Journal of clinical microbiology · 1997Article
- Genotypic identification of sequential Candida albicans isolates from AIDS patients by polymerase chain reaction techniques.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1997Article
- Variations in fluconazole susceptibility and DNA subtyping of multiple Candida albicans colonies from patients with AIDS and oral candidiasis suffering one or more episodes of infection.Journal of clinical microbiology · 1997Article
- Efficacy of D0870 treatment of experimental Candida vaginitis.Antimicrobial agents and chemotherapy · 1997Article
- Azole resistance in Candida.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1997Review
- Review
- Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance.Antimicrobial agents and chemotherapy · 1996Article
- Comparative resistance of Candida albicans clinical isolates to fluconazole and itraconazole in vitro and in vivo in a murine model.Antimicrobial agents and chemotherapy · 1996Article
- Variation in fluconazole efficacy for Candida albicans strains sequentially isolated from oral cavities of patients with AIDS in an experimental murine candidiasis model.Antimicrobial agents and chemotherapy · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We characterized Candida albicans strains responsible for recurrent oropharyngeal candidosis (OPC) in four patients with AIDS who developed clinical and mycological resistance to fluconazole (FCZ). Karyotype and restriction fragment length polymorphism analyses were performed on the clonal populations to differentiate relapse from reinfection, and the results were assessed with those of serotype and FCZ MICs. Despite the polymorphism in chromosomal bands larger than 2.2 Mbp related to an intraclonal variation, karyotype analysis showed a single strain type attributable to each patient. On the other hand, EcoRI and HinfI restriction fragments revealed a polymorphism for one patient between the first sample and the subsequent ones, relevant to the acquisition of a new strain causing the following episodes of OPC. This result coincided with switching of the serotype and with the acquisition of a resistance to FCZ. For the other three patients, the similarity of the DNA electrophoretic patterns and the serotype of the samples suggested that recurrence can be due to the initial strain that generates FCZ resistance. Although useful for epidemiological studies, molecular typing methods seem to be inadequate to detect the acquisition of FCZ resistance.
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