ArticleThe Journal of clinical investigation1993
Infusion of platelet-derived growth factor or basic fibroblast growth factor induces selective glomerular mesangial cell proliferation and matrix accumulation in rats.
Article in The Journal of clinical investigation, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 251 citations in OpenAlex.
- Cellular crosstalk of glomerular endothelial cells and podocytes in diabetic kidney disease.Journal of cell communication and signaling · 2022Review
- The Role of Platelets in Diabetic Kidney Disease.International journal of molecular sciences · 2022Review
- Serum IP-10 is useful for identifying renal and overall disease activity in pediatric systemic lupus erythematosus.Pediatric nephrology (Berlin, Germany) · 2018Article
- Article
- Cold Shock Proteins Mediate GN with Mesangioproliferation.Journal of the American Society of Nephrology : JASN · 2016Article
- Conditional Deletion of Smad1 Ameliorates Glomerular Injury in Progressive Glomerulonephritis.Scientific reports · 2016Article
- Role of Receptor Tyrosine Kinase Signaling in Renal Fibrosis.International journal of molecular sciences · 2016Review
- Pbx1-dependent control of VMC differentiation kinetics underlies gross renal vascular patterning.Development (Cambridge, England) · 2015Article
- Signal transduction in podocytes--spotlight on receptor tyrosine kinases.Nature reviews. Nephrology · 2014Review
- Tyrosine kinases inhibition by Imatinib slows progression in chronic anti-thy1 glomerulosclerosis of the rat.BMC nephrology · 2013Article
- Anti-proliferative actions of T-type calcium channel inhibition in Thy1 nephritis.The American journal of pathology · 2013Article
- The PDGF family in renal fibrosis.Pediatric nephrology (Berlin, Germany) · 2012Review
- Is There a Role for Mammalian Target of Rapamycin Inhibition in Renal Failure due to Mesangioproliferative Nephrotic Syndrome?International journal of nephrology · 2012Article
- Article
- Targeting non-malignant disorders with tyrosine kinase inhibitors.Nature reviews. Drug discovery · 2010Review
- Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
- Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing.The American journal of pathology · 2006Article
- Cardiovascular gene delivery: The good road is awaiting.Advanced drug delivery reviews · 2006Review
- TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk.The EMBO journal · 2005Article
- Novel therapeutic approaches for progressive renal disorders by targeting glomerular component mesangial and endothelial cells.Clinical and experimental nephrology · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Mesangial cell (MC) proliferation and extracellular matrix expansion are involved in the pathogenesis of glomerulosclerosis and renal failure. In vitro, PDGF and basic fibroblast growth factor (bFGF) regulate MC proliferation and/or matrix production. To elucidate the role of PDGF and bFGF in vivo, equimolar concentrations of recombinant PDGF-BB or bFGF or vehicle were infused intravenously into rats over a 7-d period. Rats were either nonmanipulated ("normals") or had received a subnephritogenic dose of anti-MC antibody ("anti-Thy 1.1 rats") before the infusion period. Glomerular cell proliferation (anti-proliferating cell nuclear antigen immunostaining) on days 2, 4, and 7 was unchanged in vehicle-infused normals or anti-Thy 1.1 rats. PDGF infusion increased glomerular cell proliferation 32-fold in anti-Thy 1.1 rats and an 11-fold in normals on day 2. bFGF increased glomerular cell proliferation fourfold in anti-Thy 1.1 rats but was ineffective in normals. Induction of cell proliferation in all kidneys was limited to the glomerulus. The majority of proliferating cells were identified as MC by double immunolabeling. No significant proteinuria, glomerular leukocyte, or platelet influx developed in any group. Glomerular matrix expansion with increased deposition of type IV collagen, laminin, and fibronectin, as well as upregulated laminin and collagen IV mRNA expression was confined to PDGF-infused anti-Thy 1.1 rats. These results show that PDGF and, to a lesser degree, bFGF are selective MC mitogens in vivo and that previous subclinical injury can enhance this MC response. The data thereby support a role of these cytokines in the pathogenesis of glomerulosclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.