ArticleClinical and experimental immunology1993
Natural and acquired resistance to Leishmania: cellular activation by Leishmania aethiopica of mononuclear cells from unexposed individuals is through the stimulation of natural killer (NK) cells.
Article in Clinical and experimental immunology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- From dogma to data: charting a path forward for clinico-immunological research in Ethiopian cutaneous leishmaniasis.Infectious diseases of poverty · 2026Review
- Cutaneous Leishmaniasis Due toEClinicalMedicine · 2018Review
- Immunologic Markers of Protection in Leishmania (Viannia) braziliensis Infection: A 5-Year Cohort Study.The Journal of infectious diseases · 2016Article
- Vaccine Development Against Leishmania donovani.Frontiers in immunology · 2012Article
- Mononuclear cells from patients recovered from cutaneous leishmaniasis respond to Leishmania major amastigote class I nuclease with a predominant Th1-like response.Clinical and experimental immunology · 2005Article
- Evaluation of amastigote reactive cells in human cutaneous leishmaniasis caused by Leishmania aethiopica.Clinical and experimental immunology · 2003Article
- Live Leishmania promastigotes can directly activate primary human natural killer cells to produce interferon-gamma.Clinical and experimental immunology · 2003Article
- Induction and abrogation of LACK reactive cells in the evolution of human leishmaniasis.Clinical and experimental immunology · 2001Article
- Differential induction of cellular responses by live and dead Leishmania promastigotes in healthy donors.Clinical and experimental immunology · 2001Article
- Role of Leishmania donovani and its lipophosphoglycan in CD4+ T-cell activation-induced human immunodeficiency virus replication.Infection and immunity · 1999Article
- Natural killer cells in cross-regulation of IL-12 by IL-10 in Leishmania antigen-stimulated blood donor cells.Clinical and experimental immunology · 1999Article
- Indications of the protective role of natural killer cells in human cutaneous leishmaniasis in an area of endemicity.Infection and immunity · 1998Article
- Interferon-gamma (IFN-gamma) production by human T lymphocytes upon Legionella pneumophila stimulation in vitro.Clinical and experimental immunology · 1995Article
- Recombinant LPG3 Stimulates IFN-Γ and TNF-A Secretion by Human NK Cells.Iranian journal of parasitologyArticle
- Recombinant LPG3 Stimulates IFN-Γ and TNF-Α Secretion by Human NK Cells.Iranian journal of parasitologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells from normal non-Leishmania-exposed individuals could respond in vitro by proliferation and interferon-gamma (IFN-gamma) production to Leishmania aethiopica stimulation. The main cell type that appeared to be activated following such stimulation was CD3-, CD16+/56+, i.e. NK cells. Of the few CD3+ cells responding, an involvement of CD8+ cells was evident in the absence of activation of CD4+ cells in normal individuals, while a different feature was observed when patients' cells were investigated. Cells from patients with L. aethiopica infection did not show this NK response, but rather the CD4+ cells were the prominent responding cells. No evidence of the involvement of superantigens or cells utilizing the gamma delta T cell receptor (gamma delta cells) in the response of unexposed individuals was noted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.