ArticleProceedings of the National Academy of Sciences of the United States of America1993
Sperm 1: a POU-domain gene transiently expressed immediately before meiosis I in the male germ cell.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 50 citations in OpenAlex.
- The functional diversity of the POUV-class proteins across vertebrates.Open biology · 2022Review
- Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming.Cellular and molecular life sciences : CMLS · 2018Review
- Dynamic reorganization of open chromatin underlies diverse transcriptomes during spermatogenesis.Nucleic acids research · 2018Article
- Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids.The EMBO journal · 2008Article
- Targeted inactivation of testicular nuclear orphan receptor 4 delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis.Molecular and cellular biology · 2004Article
- Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Regulation of IkappaBbeta expression in testis.Molecular biology of the cell · 2002Article
- Paranodal junction formation and spermatogenesis require sulfoglycolipids.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1.The EMBO journal · 2000Article
- Functional analysis of the endothelial cell-specific Tie2/Tek promoter identifies unique protein-binding elements.The Biochemical journal · 1998Article
- POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element.Molecular and cellular biology · 1998Article
- POU domain transcription factors in embryonic development.Molecular biology reports · 1997Review
- Reduced fertility in mice deficient for the POU protein sperm-1.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- The regulator of early gliogenesis glial cells missing is a transcription factor with a novel type of DNA-binding domain.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Class III POU genes of zebrafish are predominantly expressed in the central nervous system.Nucleic acids research · 1996Article
- POU-domain gene expression during spermatogenesis.World journal of urology · 1996Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Members of the POU-domain gene family encode for transcriptional regulatory molecules that are important for terminal differentiation of several organ systems, including anterior pituitary, sensory neurons, and B lymphocytes. We have identified a POU-domain factor, referred to as sperm 1 (Sprm-1). This factor is most related to the transactivator Oct-3/4, which is expressed in the early embryo, primordial germ cells, and the egg. However, in contrast with Oct-3/4, rat Sprm-1 is selectively expressed during a 36- to 48-hr period immediately preceding meiosis I in male germ cells. Although the POU-domain of Sprm-1 is divergent from the POU-domains of Oct-1 and Oct-2, random-site-selection assay reveals that Sprm-1 preferentially binds to a specific variant of the classic octamer DNA-response element in which the optimal sequence differs from that preferred by Oct-1 and Pit-1. These data suggest that the Sprm-1 gene encodes a DNA-binding protein that may exert a regulatory function in meiotic events that are required for terminal differentiation of the male germ cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.