ArticleInfection and immunity1993
Gamma interferon-dependent temporary resistance to acute Toxoplasma gondii infection independent of CD4+ or CD8+ lymphocytes.
Article in Infection and immunity, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Animal Models for Toxoplasma gondii Infection.Current protocols · 2023Article
- NK Cells Negatively Regulate CD8 T Cells to Promote Immune Exhaustion and ChronicFrontiers in cellular and infection microbiology · 2020Article
- Diverse roles for T-bet in the effector responses required for resistance to infection.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Toxoplasma gondii profilin promotes recruitment of Ly6Chi CCR2+ inflammatory monocytes that can confer resistance to bacterial infection.PLoS pathogens · 2014Article
- Contribution of Thy1+ NK cells to protective IFN-γ production during Salmonella typhimurium infections.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Immune response and immunopathology during toxoplasmosis.Seminars in immunopathology · 2012Review
- Infection-induced regulation of natural killer cells by macrophages and collagen at the lymph node subcapsular sinus.Cell reports · 2012Article
- Anti-CD25 antibody-mediated depletion of effector T cell populations enhances susceptibility of mice to acute but not chronic Toxoplasma gondii infection.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma production.The Journal of experimental medicine · 2007Article
- Exacerbated susceptibility to infection-stimulated immunopathology in CD1d-deficient mice.Journal of immunology (Baltimore, Md. : 1950) · 2005Article
- Deficient humoral responses underlie susceptibility to Toxoplasma gondii in CD4-deficient mice.Infection and immunity · 2002Article
- Intranasal immunization with SAG1 and nontoxic mutant heat-labile enterotoxins protects mice against Toxoplasma gondii.Infection and immunity · 2001Article
- B cells are essential for vaccination-induced resistance to virulent Toxoplasma gondii.Infection and immunity · 2000Article
- Toxoplasma gondii triggers granulocyte-dependent cytokine-mediated lethal shock in D-galactosamine-sensitized mice.Infection and immunity · 1998Article
- Interleukin-12, dendritic cells, and the initiation of host-protective mechanisms against Toxoplasma gondii.The Journal of experimental medicine · 1997Article
- Article
- Nonspecific immune responses and mechanisms of resistance to Eimeria papillata infections in mice.Infection and immunity · 1997Article
- Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii.Infection and immunity · 1997Article
- Innate immunity to Toxoplasma gondii is influenced by gender and is associated with differences in interleukin-12 and gamma interferon production.Infection and immunity · 1997Article
- Intact immune defenses are required for mice to resist the ts-4 vaccine strain of Toxoplasma gondii.Infection and immunity · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
It is well established that resistance to acute primary Toxoplasma gondii infection is mediated by a gamma interferon (IFN-gamma)-dependent mechanism. The present in vivo experiments were undertaken to investigate the cellular basis for this resistance. We show here that immunocompetent T. gondii-infected C57BL/6 (B6) mice treated with anti-IFN-gamma or with anti-Thy-1 or anti-asialo-GM1 antibodies die sooner than infected mice treated with antibodies that deplete both CD4+ and CD8+ T lymphocytes. Thy-1+ CD4- CD8- cells accumulated in the peritoneal cavities of B6 mice during the early stages of an intraperitoneal infection but did not accumulate in sham-infected control mice, and substantial numbers of Thy-1+ CD4- CD8- cells were recovered from the peritoneal cavities of infected B6 mice treated with antibodies that depleted CD4+ and CD8+ lymphocytes. Depletion of Thy-1+ cells reduced IFN-gamma to undetectable levels, whereas depletion of CD4+ and CD8+ cells did not reduce IFN-gamma levels. Thus T. gondii infection in immunocompetent B6 mice elicits Thy-1+ CD4- CD8- cells which either produce protective IFN-gamma themselves or control its production by other cells. It is likely that the function of these Thy-1+ CD4- CD8- cells is to control T. gondii tachyzoites during the early stages of primary infection before specific CD4(+)- and/or CD8(+)-dependent immunity develops.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.