ArticleThe EMBO journal1993
More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing.
Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 128 citations in OpenAlex.
- The position of premature termination codons in the hepatocyte nuclear factor -1 beta gene determines susceptibility to nonsense-mediated decay.Human genetics · 2005Trial
- In Silico Analysis Identified Putative Pathogenic Missense Single Nucleotide Polymorphisms (SNPs) in the HumanInternational journal of molecular sciences · 2025Article
- HNF1α upregulation and promoter hypermethylation as a cause of glucose dysregulation: a case-control study of Kashmiri MODY population.Journal of endocrinological investigation · 2023Article
- Structural properties of the HNF-1A transactivation domain.Frontiers in molecular biosciences · 2023Article
- Extensive germline-somatic interplay contributes to prostate cancer progression through HNF1B co-option of TMPRSS2-ERG.Nature communications · 2022Article
- Transcriptional control by HNF-1: Emerging evidence showing its role in lipid metabolism and lipid metabolism disorders.Genes & diseases · 2022Review
- Molecular diagnosis of maturity onset diabetes of the young in Iranian patients: improving management.Journal of diabetes and metabolic disorders · 2021Article
- Hepatocyte nuclear factor 1 beta: A perspective in cancer.Cancer medicine · 2021Review
- Human mutations affect the epigenetic/bookmarking function of HNF1B.Nucleic acids research · 2016Article
- Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence.Journal of structural biology · 2016Article
- Expression, Epigenetic and Genetic Changes of HNF1B in Endometrial Lesions.Pathology oncology research : POR · 2016Article
- HNF1B polymorphism influences the prognosis of endometrial cancer patients: a cohort study.BMC cancer · 2015Article
- Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk.Human molecular genetics · 2015Article
- The HMGA1-IGF-I/IGFBP system: a novel pathway for modulating glucose uptake.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Article
- Large-scale fine mapping of the HNF1B locus and prostate cancer risk.Human molecular genetics · 2011Article
- Genome-wide association study identifies a common variant associated with risk of endometrial cancer.Nature genetics · 2011Article
- Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer.BMC cancer · 2010Article
- Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells.The Journal of biological chemistry · 2010Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the isolation of cDNAs from human liver encoding several isoforms of the hepatocyte nuclear factor homeoproteins HNF1 and vHNF1 generated by the differential use of polyadenylation sites and by alternative splicing. In the novel isoforms intron sequences that are excised in the previously described forms are translated in the same frame as exon sequences until the first termination codon is encountered. Hence, the newly found isoforms all contain different C-terminal domains. For HNF1 it has been shown that its C-terminal region is responsible for the activation of transcription. In transient transfection assays the two novel HNF1 isoforms, HNF1-B and -C, transactivate 5-fold better than the previously described HNF1 protein (HNF1-A). The newly isolated isoform of vHNF1, designated vHNF1-C, is unable to transactivate and behaves as a transdominant repressor when cotransfected with HNF1-A, -B or -C. All of the different isoforms of HNF1 and vHNF1 can form homo- and heterodimers and their mRNAs are differentially expressed in fetal and adult human liver, kidney and intestine, suggesting distinct roles during development. Our studies show that the transactivation domain of the members of the HNF1 homeoprotein family is organized in modules which can be exchanged to generate either more potent transcriptional activators or a transdominant repressor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.