Evidence map›Paper›PMID 7898468›Full record

ReviewMolecular and cellular biochemistry1994

Cyclic ADP-ribose: a calcium mobilizing metabolite of NAD+.

H C Lee

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular and cellular biochemistry, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
  2. Article
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  14. Extracellular synthesis of cADP-ribose from nicotinamide-adenine dinucleotide by rat cortical astrocytes in culture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

H C LeeDepartment of Physiology, Lyon Laboratory, University of Minnesota, Minneapolis 55455.
University of Minnesota · US

Funding

MECHANISM OF CALCIUM MOBILIZATIONR01HD017484 · NICHD · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LEE, HONCHEUNG · 1985 to 2000
$254k
NICHD NIH HHS HD17484
6 · The paper itself

Abstract

Mobilization of Ca+2 from intracellular stores is a signalling mechanism that is of fundamental importance to many cellular processes. It is mediated by two major mechanisms, the inositol 1,4,5-trisphosphate pathway and the Ca+2-induced Ca+2 release process. A naturally occurring metabolite of NAD+ called cyclic ADP-ribose has been discovered recently and shown to be as effective as inositol 1,4,5-trisphosphate in mobilizing Ca+2 stores in sea urchin eggs, a marine invertebrate cell, as well as several mammalian cells. This article reviews the accumulating evidence that indicates cyclic ADP-ribose may function as a physiological regulator of the Ca+2-induced Ca+2 release process and the current knowledge about its receptor as well as the enzymes involved in its metabolism.

Indexed as

Antigens, CDAdenosine Diphosphate RiboseADP-ribosyl CyclaseADP-ribosyl Cyclase 1AnimalsAntigens, DifferentiationCalciumCyclic ADP-RiboseHumansMembrane GlycoproteinsMolecular StructureNADN-Glycosyl HydrolasesReceptors, Cell SurfaceAdenosine Diphosphate RiboseADP-ribosyl CyclaseADP-ribosyl Cyclase 1Antigens, CDAntigens, DifferentiationCalciumCD38 protein, humanCyclic ADP-Ribosecyclic ADP-ribose receptorMembrane GlycoproteinsNADN-Glycosyl HydrolasesReceptors, Cell Surface

Identifiers

PMID7898468
OpenAlexW2168839532

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.