ArticleThe Journal of cell biology1995
Annexin XIIIb: a novel epithelial specific annexin is implicated in vesicular traffic to the apical plasma membrane.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Revisiting the role of Annexins in membrane trafficking.Cellular and molecular life sciences : CMLS · 2025Review
- Annexins and cardiovascular diseases: Beyond membrane trafficking and repair.Frontiers in cell and developmental biology · 2022Review
- The MAL Protein, an Integral Component of Specialized Membranes, in Normal Cells and Cancer.Cells · 2021Review
- Annexin-phospholipid interactions. Functional implications.International journal of molecular sciences · 2013Article
- Hepatocyte polarity.Comprehensive Physiology · 2013Review
- Annexin A2 at the interface of actin and membrane dynamics: a focus on its roles in endocytosis and cell polarization.International journal of cell biology · 2012Article
- Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function.Molecular biology of the cell · 2011Article
- Studies on localization and function of annexin A4a within urinary bladder epithelium using a mouse knockout model.American journal of physiology. Renal physiology · 2008Article
- Article
- The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans.The Journal of cell biology · 2006Article
- Caveolin-1 is not essential for biosynthetic apical membrane transport.Molecular and cellular biology · 2005Article
- Structure-function relationship in annexin A13, the founder member of the vertebrate family of annexins.The Biochemical journal · 2005Article
- LMP2A does not require palmitoylation to localize to buoyant complexes or for function.Journal of virology · 2004Article
- The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture.Oncogene · 2004Review
- Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Structural and functional characterization of recombinant mouse annexin A11: influence of calcium binding.The Biochemical journal · 2003Article
- Annexin II regulates multivesicular endosome biogenesis in the degradation pathway of animal cells.The EMBO journal · 2003Article
- Annexin A4 reduces water and proton permeability of model membranes but does not alter aquaporin 2-mediated water transport in isolated endosomes.The Journal of general physiology · 2003Article
- Nonpolarized cells selectively sort apical proteins from cell surface to a novel compartment, but lack apical retention mechanisms.Molecular biology of the cell · 2002Article
- Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb.The Journal of cell biology · 2000Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sorting of apical and basolateral proteins into vesicular carriers takes place in the trans-Golgi network (TGN) in MDCK cells. We have previously analyzed the protein composition of immunoisolated apical and basolateral transport vesicles and have now identified a component that is highly enriched in apical vesicles. Isolation of the encoding cDNA revealed that this protein, annexin XIIIb, is a new isoform of the epithelial specific annexin XIII sub-family which includes the previously described intestine-specific annexin (annexin XIIIa; Wice, B. M., and J. I. Gordon. 1992. J. Cell Biol. 116:405-422). Annexin XIIIb differs from annexin XIIIa in that it contains a unique insert of 41 amino acids in the NH2 terminus and is exclusively expressed in dog intestine and kidney. Immunofluorescence microscopy demonstrated that annexin XIIIb was localized to the apical plasma membrane and underlying punctate structures. Since annexins have been suggested to play a role in membrane-membrane interactions in exocytosis and endocytosis, we investigated whether annexin XIIIb is involved in delivery to the apical cell surface. To this aim we used permeabilized MDCK cells and a cytosol-dependent in vitro transport assay. Antibodies specific for annexin XIIIb significantly inhibited the transport of influenza virus hemagglutinin from the TGN to the apical plasma membrane while the transport of vesicular stomatitis virus glycoprotein to the basolateral cell surface was unaffected. We propose that annexin XIIIb plays a role in vesicular transport to the apical plasma membrane in MDCK cells.
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