ReviewThe Histochemical journal1994
A re-evaluation of the tissue distribution and physiology of xanthine oxidoreductase.
Review in The Histochemical journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 74 citations in OpenAlex.
- Role of leucocytes in free radical production during myocardial revascularisation.Heart (British Cardiac Society) · 1997Trial
- The Role of Xanthine Oxidase in Pregnancy Complications: A Systematic Review.Antioxidants (Basel, Switzerland) · 2024Review
- Xanthine Oxidoreductase in the Pathogenesis of Endothelial Dysfunction: An Update.Current hypertension reviews · 2024Review
- Molecular mechanistic insight into the anti-hyperuricemic effect of Eucommia ulmoides in mice and rats.Pharmaceutical biology · 2019Article
- Biochemical basis and metabolic interplay of redox regulation.Redox biology · 2019Review
- Xanthine Oxidoreductase-Derived Reactive Species: Physiological and Pathological Effects.Oxidative medicine and cellular longevity · 2016Review
- The C-terminal peptide plays a role in the formation of an intermediate form during the transition between xanthine dehydrogenase and xanthine oxidase.The FEBS journal · 2015Article
- Article
- Amelioration of experimental colitis by Astragalus membranaceus through anti-oxidation and inhibition of adhesion molecule synthesis.World journal of gastroenterology · 2005Article
- Oxidases and oxygenases in regulation of vascular nitric oxide signaling and inflammatory responses.Immunologic research · 2002Review
- Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Interaction of hypoxanthine/xanthine oxidase with nitrergic relaxation in the porcine gastric fundus.British journal of pharmacology · 2000Article
- Article
- In situ heterogeneity of peroxisomal oxidase activities: an update.The Histochemical journal · 1996Review
- Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Ultrastructural localization of xanthine oxidase activity in the digestive tract of the rat.The Histochemical journal · 1995Article
- Analysis of enzyme reactions in situ.The Histochemical journal · 1995Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Xanthine oxidoreductase is an enzyme which has the unusual property that it can exist in a dehydrogenase form which uses NAD+ and an oxidase form which uses oxygen as electron acceptor. Both forms have a high affinity for hypoxanthine and xanthine as substrates. In addition, conversion of one form to the other may occur under different conditions. The exact function of the enzyme is still unknown but it seems to play a role in purine catabolism, detoxification of xenobiotics and antioxidant capacity by producing urate. The oxidase form produces reactive oxygen species and, therefore, the enzyme is thought to be involved in various pathological processes such as tissue injury due to ischaemia followed by reperfusion, but its role is still a matter of debate. The present review summarizes information that has become available about the enzyme. Interpretations of contradictory findings are presented in order to reduce confusion that still exists with respect to the role of this enzyme in physiology and pathology.
Indexed as
Identifiers
7896566W2020030871What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.