ReviewGenetica1994
Genome plasticity in Plasmodium.
Review in Genetica, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- A Comparative Genomic Study of Attenuated and Virulent Strains ofPathogens (Basel, Switzerland) · 2021Article
- Antigenic diversity and immune evasion by malaria parasites.Clinical and diagnostic laboratory immunology · 2004Review
- Repetitive elements in genomes of parasitic protozoa.Microbiology and molecular biology reviews : MMBR · 2003Review
- Low-complexity regions in Plasmodium falciparum proteins.Genome research · 2001Article
- Population structure and recent evolution of Plasmodium falciparum.Proceedings of the National Academy of Sciences of the United States of America · 2000Review
- Genetic polymorphism and natural selection in the malaria parasite Plasmodium falciparum.Genetics · 1998Article
- Sequence diversity and molecular evolution of the merozoite surface antigen 2 of Plasmodium falciparum.Journal of molecular evolution · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extensive genome plasticity in Plasmodium involves frequent loss of dispensable functions under non-selective conditions, polymorphisms in subtelomeric repetitive regions, as well as rapid and apparently concerted variation in the intra-genic repetitive arrays that are typical of plasmodial antigen genes. As an example of the latter type of variation, the region of the merozoite surface antigen gene MSA-1 of Plasmodium falciparum, which encodes a tri-peptide repeat, is analysed in detail. The example illustrates how evasion of the immune defenses of the vertebrate host can be achieved through repeat homogenization mechanisms, acting at the DNA level, and leading to rapid fixation of variant epitopes. The remarkable ability of Plasmodia to utilize mechanisms which operate on its own nuclear DNA in the course of mitotic multiplication is discussed against the need of life cycle closure as a haploid unicellular. The possibility is suggested that active genomic diversification in a (clonal) multicellular population evolved as an adaptive tool.
Indexed as
Identifiers
7896147What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.