Evidence map›Paper›PMID 7896112›Full record

ArticleGenetics1994

Further examples of evolution by gene duplication revealed through DNA sequence comparisons.

T Ohta

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 106 citations in OpenAlex.

  1. Article
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  6. Article
  7. Colloquium paper: a role for relaxed selection in the evolution of the language capacity.Proceedings of the National Academy of Sciences of the United States of America · 2010
    Article
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  15. Article
  16. Article
  17. Review
  18. Accelerated regulatory gene evolution in an adaptive radiation.Proceedings of the National Academy of Sciences of the United States of America · 2001
    Article
  19. Article
  20. Genome evolution in polyploids.Plant molecular biology · 2000
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

T OhtaNational Institute of Genetics, Mishima, Japan.
National Institute of Genetics · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To test the theory that evolution by gene duplication occurs as a result of positive Darwinian selection that accompanies the acceleration of mutant substitutions, DNA sequences of recent duplication were analyzed by estimating the numbers of synonymous and nonsynonymous substitutions. For the troponin C family, at the period of differentiation of the fast and slow isoforms, amino acid substitutions were shown to have been accelerated relative to synonymous substitutions. Comparison of the first exon of alpha-actin genes revealed that amino acid substitutions were accelerated when the smooth muscle, skeletal and cardiac isoforms differentiated. Analysis of members of the heat shock protein 70 gene family of mammals indicates that heat shock responsive genes including duplicated copies are evolving rapidly, contrary to the cognitive genes which have been evolutionarily conservative. For the alpha 1-antitrypsin reactive center, the acceleration of amino acid substitution has been found for gene paris of recent duplication.

Indexed as

Models, GeneticMultigene FamilySelection, GeneticSequence Homology, Nucleic AcidActinsalpha 1-AntitrypsinAnimalsBase SequenceDNAHSP70 Heat-Shock ProteinsHumansMiceMutationRabbitsTroponinTroponin CActinsalpha 1-AntitrypsinDNAHSP70 Heat-Shock ProteinsTroponinTroponin C

Identifiers

PMID7896112
PMCPMC1206269
OpenAlexW2122951336

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.