ArticleGenetics1994
Interactions of polyhomeotic with Polycomb group genes of Drosophila melanogaster.
Article in Genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Review
- Transcriptome Analysis of Long-lived Drosophila melanogaster E(z) Mutants Sheds Light on the Molecular Mechanisms of Longevity.Scientific reports · 2019Article
- Critical genomic regulation mediated by Enhancer of Polycomb.Current genetics · 2018Review
- Functional and cancer genomics of ASXL family members.British journal of cancer · 2013Review
- Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation.Nature reviews. Molecular cell biology · 2012Review
- Cross-regulation among the polycomb group genes in Drosophila melanogaster.Molecular and cellular biology · 2004Article
- Telomeric associated sequences of Drosophila recruit polycomb-group proteins in vivo and can induce pairing-sensitive repression.Genetics · 2003Article
- Article
- Mutations in Drosophila heat shock cognate 4 are enhancers of Polycomb.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- The mcp element from the Drosophila melanogaster bithorax complex mediates long-distance regulatory interactions.Genetics · 1999Article
- RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1.The EMBO journal · 1999Article
- Article
- Expression and properties of wild-type and mutant forms of the Drosophila sex comb on midleg (SCM) repressor protein.Genetics · 1998Article
- The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression.Molecular and cellular biology · 1998Article
- The Drosophila polycomb group protein Psc contacts ph and Pc through specific conserved domains.Molecular and cellular biology · 1998Article
- The distribution of polycomb-group proteins during cell division and development in Drosophila embryos: impact on models for silencing.The Journal of cell biology · 1998Article
- The polycomb group protein complex of Drosophila melanogaster has different compositions at different target genes.Molecular and cellular biology · 1997Article
- Article
- A screen for modifiers of Deformed function in Drosophila.Genetics · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Polycomb (Pc) group genes of Drosophila are negative regulators of homeotic genes, but individual loci have pleiotropic phenotypes. It has been suggested that Pc group genes might form a regulatory hierarchy, or might be members of a multimeric complex that obeys the law of mass action. Recently, it was shown that polyhomeotic (ph) immunoprecipitates in a multimeric complex that includes Pc. Here, we show that duplications of ph suppress homeotic transformations of Pc and Pcl, supporting a mass-action model for Pc group function. We crossed ph alleles to all members of the Polycomb group, and to E(Pc) and Su(z)2 to look for synergistic effects. We observed extragenic noncomplementation between ph503 and Pc, Psc1 and Su(z)2(1) in females, and between ph409 and Sce1, ScmD1 and E(z)1 mutations in males, suggesting that these gene products might interact directly with ph. Males hemizygous for a temperature-sensitive allele, ph2, are lethal when heterozygous with mutants in Asx, Pc, Pcl, Psc, Sce and Scm, and with E(Pc) and Su(z)2. Mutations in trithorax group genes were not able to suppress the lethality of ph2/Y; Psc1/+ males. ph2 was not lethal with extra sex combs, E(z), super sex combs (sxc) or l(4)102EFc heterozygotes, but did cause earlier lethality in embryos homozygous for E(z), sxc and l(4)102EFc. However, ph503 did not enhance homeotic phenotypes of esc heterozygotes derived from homozygous esc- mothers. We examined the embryonic phenotypes of ph2 embryos that were lethal when heterozygous or homozygous for other mutations. Based on this phenotypic analysis, we suggest that ph may perform different functions in conjunction with differing subsets of Pc group genes.
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