ArticleMammalian genome : official journal of the International Mammalian Genome Society1994
Assignment of a locus for mouse lung tumor susceptibility to proximal chromosome 19.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
- The error-prone DNA polymerase ι provides quantitative resistance to lung tumorigenesis and mutagenesis in mice.Oncogene · 2014Article
- Multigenic nature of the mouse pulmonary adenoma progression 1 locus.BMC genomics · 2013Article
- Identification of fat4 and tsc22d1 as novel candidate genes for spontaneous pulmonary adenomas.Cancer research · 2011Article
- Article
- Mouse genome-wide association mapping needs linkage analysis to avoid false-positive Loci.PLoS genetics · 2009Article
- Genetic linkage between Pol iota deficiency and increased susceptibility to lung tumors in mice.Cancer science · 2005Article
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- Article
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- Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Article
- Linkage disequilibrium mapping of novel lung tumor susceptibility quantitative trait loci in mice.Oncogene · 2002Article
- Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays.Journal of medical genetics · 2002Article
- Fine chromosomal localization of the mouse Par2 gene that confers resistance against urethane-induction of pulmonary adenomas.Oncogene · 2001Article
- Review
- Linkage disequilibrium and physical mapping of Pas1 in mice.Genome research · 1999Article
- The mouse homologs of RELA and MLK3 are located within a 120-kb fragment on chromosome 19.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Sequence and chromosomal mapping of the mouse homolog (Madh4) of the human DPC4/MADH4 gene.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Pas1 is a common lung cancer susceptibility locus in three mouse strains.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have hypothesized that at least three genetic loci contribute to differences in pulmonary adenoma susceptibility between mouse strains A/J and C57BL/6J. One gene that may confer susceptibility to lung tumorigenesis is the Kras protooncogene. To identify other relevant loci involved in this polygenic trait, we determined tumor multiplicity in 56 randomly chosen N-ethyl-N-nitrosourea-treated (A/J x C57BL/6J) N1 x C57BL/6 backcross (AB6N2) progeny and correlated it with genotypes at 77 microsatellite markers spanning the genome. A correlation of lung tumor multiplicity phenotypes with genotypes of microsatellite markers on distal Chromosome (Chr) 6 in the Kras region (Pas1) was confirmed, and a new region on Chr 19 (designated Pas3) was identified that also contributes to susceptibility. Linkage analysis on Chr 19 with 270 AB6N2 mice localized the region flanked by D19Mit42 and D19Mit19 that is most closely associated with lung tumor susceptibility. The Pas3 locus may be an enhancer of the susceptibility locus on Chr 6.
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