ArticleProceedings of the National Academy of Sciences of the United States of America1995
Negative transcriptional regulation in anergic T cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 64 citations in OpenAlex.
- Transcription elements AREB6 and miR-34a affect apoptosis of PAMs by regulating the expression of SS2-related gene PPP1R11.Cell cycle (Georgetown, Tex.) · 2019Article
- T cell ignorance is bliss: T cells are not tolerized by Langerhans cells presenting human papillomavirus antigens in the absence of costimulation.Papillomavirus research (Amsterdam, Netherlands) · 2016Article
- IDO-expressing regulatory dendritic cells in cancer and chronic infection.Journal of molecular medicine (Berlin, Germany) · 2008Review
- Transcriptional regulation of T cell tolerance.Seminars in immunology · 2007Review
- Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo.The Journal of experimental medicine · 1998Article
- Biochemical features of anergic T cells.Immunologic research · 1998Review
- Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6.Molecular and cellular biology · 1998Article
- Translational control of interleukin 2 messenger RNA as a molecular mechanism of T cell anergy.The Journal of experimental medicine · 1996Article
- Models of T cell anergy: is there a common molecular mechanism?The Journal of experimental medicine · 1996Review
- DNA loops induced by cooperative binding of transcriptional activator proteins and preinitiation complexes.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Induction of carcinoma cell migration on vitronectin by NF-kappa B-dependent gene expression.Molecular biology of the cell · 1995Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Anergy is a mechanism of T-lymphocyte tolerance induced by antigen-receptor stimulation in the absence of costimulation, whereby T cells exhibit a defect in antigen-induced transcription of the interleukin 2 (IL-2) gene. Here we present evidence for a mechanism of negative IL-2 gene regulation in anergic T cells. High amounts of binding activity to the negative regulatory element A (NRE-A) of the IL-2 promotor were detected in nuclear extracts from human T cells shortly after induction of anergy. Rapid induction of this nuclear complex is blocked by cyclosporin A and is found to be independent of protein synthesis. Plasmid DNAs, containing either the human phorbol 12-myristate 13-acetate-responsive element (PRE) or both NRE-A and PRE, were used as template for in vitro transcription assays in the presence of T-cell nuclear extracts. Under these conditions nuclear extracts from both anergic and rested T-cell clones, after crosslinking of CD3 and CD28, induced transcription of plasmids containing only PRE. However, when plasmids containing NRE-A and PRE were used, transcription was only induced by nuclear extracts from rested but not anergic T cells. These findings suggest the functional relevance of transcriptional repression of the IL-2 gene in anergic T cells.
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