ArticleProceedings of the National Academy of Sciences of the United States of America1995
Heat shock protein hsp70 accelerates the recovery of heat-shocked mammalian cells through its modulation of heat shock transcription factor HSF1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 96 citations in OpenAlex.
- Stress biology: Complexity and multifariousness in health and disease.Cell stress & chaperones · 2024Article
- Article
- An artificial HSE promoter for efficient and selective detection of heat shock pathway activity.Cell stress & chaperones · 2015Article
- Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.Chemical research in toxicology · 2012Review
- Heat shock factor 1 protects against lung mycoplasma pneumoniae infection in mice.Journal of innate immunity · 2012Article
- Heat shock proteins as biomarkers for the rapid detection of brain and spinal cord ischemia: a review and comparison to other methods of detection in thoracic aneurysm repair.Cell stress & chaperones · 2011Review
- Modulation of Drosophila heat shock transcription factor activity by the molecular chaperone DROJ1.The EMBO journal · 2001Article
- Fever and the heat shock response: distinct, partially overlapping processes.Cell stress & chaperones · 2000Review
- The chaperone function of hsp70 is required for protection against stress-induced apoptosis.Molecular and cellular biology · 2000Article
- Heat shock-induced arrests in different cell cycle phases of rat C6-glioma cells are attenuated in heat shock-primed thermotolerant cells.Cell proliferation · 2000Article
- The protein kinase inhibitor, H-7, suppresses heat induced activation of heat shock transcription factor 1.Molecular and cellular biochemistry · 1999Article
- Heat shock factor function and regulation in response to cellular stress, growth, and differentiation signals.Gene expression · 1999Review
- Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs.The Journal of clinical investigation · 1998Article
- Nitric oxide induces heat-shock protein 70 expression in vascular smooth muscle cells via activation of heat shock factor 1.The Journal of clinical investigation · 1997Article
- Heat shock factor-1 protein in heat shock factor-1 gene-transfected human epidermoid A431 cells requires phosphorylation before inducing heat shock protein-70 production.The Journal of clinical investigation · 1997Article
- Modulation of thermal induction of hsp70 expression by Ku autoantigen or its individual subunits.Molecular and cellular biology · 1996Article
- Activation of heat shock protein (hsp)70 and proto-oncogene expression by alpha1 adrenergic agonist in rat aorta with age.The Journal of clinical investigation · 1996Article
- Suppression of heat-induced hsp70 expression by the 70-kDa subunit of the human Ku autoantigen.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The role of mammalian 70-kDa heat shock protein (hsp70) in regulating cellular response to heat shock was examined by using three closely related rat cells: control Rat-1 cells, thermotolerant Rat-1 (TT Rat-1) cells, and heat-resistant M21 cells, a derivative of Rat-1 cells that constitutively overexpress human hsp70. In all these cells, after a prescribed heat shock, the level of the phosphorylated form of heat shock transcription factor HSF1 and that of HSF1 capable of binding to its cognitive DNA sequence heat shock element (HSE) exhibit similar time dependence. The amount of a constitutive HSE-binding activity (CHBA), on the other hand, inversely correlates with those of the two aforementioned forms of HSF1. The recovery kinetics from heat shock are different for the three cell lines, with the thermal-resistant TT Rat-1 and M21 cells showing faster recovery in terms of the state of phosphorylation of HSF1 and its ability to bind HSE or in terms of the reappearance of CHBA. Treatment with okadaic acid, a serine/threonine phosphatase inhibitor, delays the recovery kinetics of Rat-1 cells but not that of thermal-resistant M21 cells. These results are interpreted in terms of a role for hsp70 in the recovery of heat-shocked mammalian cells.
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