ArticleProceedings of the National Academy of Sciences of the United States of America1995
cDNA sequence and expression pattern of the putative pheromone carrier aphrodisin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 40 citations in OpenAlex.
- Ligand binding and partial characterization of sex-specifically expressed lipocalins of submandibular and lacrimal glands of Syrian hamsters.Scientific reports · 2025Article
- Odorant-binding proteins in canine anal sac glands indicate an evolutionarily conserved role in mammalian chemical communication.BMC ecology and evolution · 2021Article
- Identification of potential chemosignals in the European water vole Arvicola terrestris.Scientific reports · 2019Article
- The olfactory secretome varies according to season in female sheep and goat.BMC genomics · 2019Article
- Reverse chemical ecology: Olfactory proteins from the giant panda and their interactions with putative pheromones and bamboo volatiles.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Novel OBP genes similar to hamster Aphrodisin in the bank vole, Myodes glareolus.BMC genomics · 2010Article
- Uterocalin, a lipocalin provisioning the preattachment equine conceptus: fatty acid and retinol binding properties, and structural characterization.The Biochemical journal · 2001Article
- The lipocalin protein family: structure and function.The Biochemical journal · 1996Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cDNA sequence for aphrodisin, a lipocalin from hamster vaginal discharge which is involved in pheromonal activity, has been determined. Corresponding genomic clones were isolated and the promoter region was identified. Primer extension analysis revealed an adenosine residue as the main transcription initiation site, located 50 bp upstream of the translation start codon ATG, which is surrounded by a typical Kozak sequence. However, data from polymerase chain reaction analysis suggest the existence of at least one alternative transcription initiation site. The aphrodisin cDNA is 732 bp long and codes for the mature 151-aa aphrodisin and an additional N-terminal 16-aa secretory signal peptide. The 3' nontranslated region is 228 bp long. Among the known sequences, the aphrodisin cDNA shares the highest homology with the rat odorant-binding protein cDNA (45%), which verifies the protein data. Vaginal tissue and Bartholin's glands are the main aphrodisin gene-expressing tissues of the female hamster genital tract, as demonstrated by Northern blot analysis. Under less stringent hybridization conditions, RNA isolated from rat Bartholin's glands also showed a signal, indicating the occurrence of aphrodisin-related mRNA in this species.
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