ArticleProceedings of the National Academy of Sciences of the United States of America1995
Analysis of the human guanylin gene and the processing and cellular localization of the peptide.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 57 citations in OpenAlex.
- Gut reactions and gut instincts: regulation of intestinal homeostasis by receptor guanylyl cyclase C (GC-C).The Biochemical journal · 2025Review
- Review
- Enteroendocrine cell regulation of the gut-brain axis.Frontiers in neuroscience · 2023Review
- Decreased Colonic Guanylin/Uroguanylin Expression and Dried Stool Property in Mice With Social Defeat Stress.Frontiers in physiology · 2020Article
- Characterisation of proguanylin expressing cells in the intestine - evidence for constitutive luminal secretion.Scientific reports · 2019Article
- Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa.Cell and tissue research · 2016Article
- Current understanding of guanylin peptides actions.ISRN nephrology · 2013Review
- Pendrin, a novel transcriptional target of the uroguanylin system.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2013Review
- Phosphate sensing.Current opinion in nephrology and hypertension · 2009Review
- Mechanisms of actions of guanylin peptides in the kidney.Pflugers Archiv : European journal of physiology · 2005Review
- HCC-2, a human chemokine: gene structure, expression pattern, and biological activity.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Localization, expression, and characterization of guanylin in the rat adrenal medulla.Histochemistry and cell biology · 1996Article
- Bronchiolar nonciliated secretory (Clara) cells: source of guanylin in the mammalian lung.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complete cell biological analysis of human guanylin, a recently discovered regulatory peptide, is offered in this investigation: (i) the nucleotide sequence of the gene, (ii) the isolation and characterization of its circulating molecular form, and (iii) its localization in enterochromaffin cells of the gut. As determined by molecular cloning, DNA sequencing, and comparison with the known cDNA sequence, the approximately 2.6-kbp large gene consists of three exons interrupted by two introns. The putative promoter region contains a TTTAAAA sequence motif and several potential binding sites for transcription factors such as AP-1, AP-2, Sp 1, and glucocorticoid receptors. The isolated hormonal form of guanylin is a 94-amino acid peptide with a molecular mass of 10.3 kDa. Western blot analysis of RP-HPLC fractions from blood plasma confirms this molecular form. Thus, guanylin is synthesized by gut enterochromaffin cells as a prohormone of 115 amino acids and is processed to the molecular form of 94 amino acids circulating in the blood.
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