ArticleProceedings of the National Academy of Sciences of the United States of America1995
Transposon-induced promoter scrambling: a mechanism for the evolution of new alleles.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- How important are transposons for plant evolution?Nature reviews. Genetics · 2013Review
- Functional analysis of the HS185 regulatory element in the rice HSP70 promoter.Molecular biology reports · 2012Article
- Small RNAs, DNA methylation and transposable elements in wheat.BMC genomics · 2010Article
- Mechanisms and evolution of control logic in prokaryotic transcriptional regulation.Microbiology and molecular biology reviews : MMBR · 2009Review
- Article
- Transcription factor CBF4 is a regulator of drought adaptation in Arabidopsis.Plant physiology · 2002Article
- Dynamics of mobile element activity in chalcone synthase loci in the common morning glory (Ipomoea purpurea).Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- A novel Alu-like element rearranged in the dystrophin gene causes a splicing mutation in a family with X-linked dilated cardiomyopathy.American journal of human genetics · 1998Article
- Transcriptional regulators and the evolution of plant form.The Plant cell · 1998Review
- Article
- Article
- Mu element-generated gene conversions in maize attenuate the dominant knotted phenotype.Genetics · 1997Article
- Transposable elements as sources of variation in animals and plants.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Retrotransposon insertion into the maize waxy gene results in tissue-specific RNA processing.The Plant cell · 1997Article
- Molecular Genetics of Crassulacean Acid Metabolism.Plant physiology · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied a germinal revertant of the Mutator (Mu3)-induced mutation (Adh1-3F1124) of the maize alcohol dehydrogenase 1 gene (adh1). Transposon Mu3 was inserted at the TATA box of the promoter. The excision of Mu3 caused a complex, multibreakpoint DNA rearrangement with deletion, inverted duplication, and inversions affecting 430 nucleotides in the promoter region. These changes led to an unusual pattern of adh1 gene expression: increased levels of enzyme activity in one organ, decreased levels in another, and almost unchanged levels in a third organ. The evolutionary impact of transposon-induced promoter scrambling on generation of allelic diversity is discussed. We present a fragmentation model to help explain how transposon excision could induce multiple breakpoint aberrations without involving a homologous chromosome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.