ArticleProceedings of the National Academy of Sciences of the United States of America1995
Exon skipping by overexpression of a Drosophila heterogeneous nuclear ribonucleoprotein in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoproteins modulates splicing.Nucleic acids research · 2009Article
- Genome-wide analysis of alternative pre-mRNA splicing and RNA-binding specificities of the Drosophila hnRNP A/B family members.Molecular cell · 2009Article
- Drosophila hnRNP A1 homologs Hrp36/Hrp38 enhance U2-type versus U12-type splicing to regulate alternative splicing of the prospero twintron.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Evidence for splice site pairing via intron definition in Schizosaccharomyces pombe.Molecular and cellular biology · 2000Article
- Selection of alternative 5' splice sites: role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNP A1.Molecular and cellular biology · 2000Article
- The levels of the bancal product, a Drosophila homologue of vertebrate hnRNP K protein, affect cell proliferation and apoptosis in imaginal disc cells.Molecular and cellular biology · 1999Article
- Separable roles in vivo for the two RNA binding domains of Drosophila A1-hnRNP homolog.RNA (New York, N.Y.) · 1998Article
- Distinct functions of the closely related tandem RNA-recognition motifs of hnRNP A1.RNA (New York, N.Y.) · 1998Article
- Regulation of Ich-1 pre-mRNA alternative splicing and apoptosis by mammalian splicing factors.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Mutations in the hrp48 gene, which encodes a Drosophila heterogeneous nuclear ribonucleoprotein particle protein, cause lethality and developmental defects and affect P-element third-intron splicing in vivo.Molecular and cellular biology · 1997Article
- Retrotransposon insertion into the maize waxy gene results in tissue-specific RNA processing.The Plant cell · 1997Article
- Altered levels of the Drosophila HRB87F/hrp36 hnRNP protein have limited effects on alternative splicing in vivo.Molecular biology of the cell · 1996Article
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5 authors at 1 institution in 1 country.
Funding
Abstract
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are abundant RNA-binding proteins that are implicated in splicing regulation. Here we investigate the role of a Drosophila hnRNP in splicing regulation in living animals. We find that overexpression of the Drosophila hnRNP HRB98DE leads to skipping of all internal exons in the Drosophila dopa decarboxylase (Ddc) pre-mRNA in vivo. These results indicate that HRB98DE has a splicing activity that promotes use of terminal splice sites. The effect of excess HRB98DE on Ddc splicing is transient, even though high levels of HRB98DE persist for at least 24 hr. This suggests that Drosophila larvae can induce a compensating mechanism to counteract the effects of excess HRB98DE.
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