ArticlePflugers Archiv : European journal of physiology1994
Quantitative estimation of the area of luminal and basolateral membranes of rat parotid acinar cells: some physiological applications.
Article in Pflugers Archiv : European journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- New saliva secretion model based on the expression of NaPflugers Archiv : European journal of physiology · 2018Article
- Mechanisms Underlying Activation of α₁-Adrenergic Receptor-Induced Trafficking of AQP5 in Rat Parotid Acinar Cells under Isotonic or Hypotonic Conditions.International journal of molecular sciences · 2016Article
- Apical Ca2+-activated potassium channels in mouse parotid acinar cells.The Journal of general physiology · 2012Article
- Efficiency of primary saliva secretion: an analysis of parameter dependence in dynamic single-cell and acinus models, with application to aquaporin knockout studies.The Journal of membrane biology · 2012Article
- A dynamic model of saliva secretion.Journal of theoretical biology · 2010Article
- Radioprotective effect of heat shock protein 25 on submandibular glands of rats.The American journal of pathology · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knowledge of luminal and basolateral acinar cell membrane areas of the secretory endpieces is a prerequisite for a detailed quantitative analysis of the ion transport involved in secretion of the primary saliva. In the present study, these areas were estimated in rat parotid acinar cells using standard stereological methods. A total of 480 micrographs--obtained by random sampling from eight glands from four rats--were analysed at a final magnification of 40000x. Expressed per unit cell volume, the area of the luminal acinar cell membrane was: 0.125 micron 2.micron-3 (SEM = 0.027 micron 2.micron-3, n = 4 animals) and the area of the basolateral membrane was: 1.54 microns 2.micron-3 (SEM = 0.085 micron 2.micron-3, n = 4 animals). These figures make it possible to perform a synthesis based upon different categories of experimental data, e.g. on ion fluxes, membrane potentials and single-channel conductances. Thus, we have estimated the density of open, low-conductance Cl- channels in the luminal membrane--which are not readily accessible for direct, patch-clamp analysis--to be approximately 18 channels per microns 2 in the stimulated state.
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