ArticleMolecular and cellular biology1995
p13suc1 of Schizosaccharomyces pombe regulates two distinct forms of the mitotic cdc2 kinase.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 46 citations in OpenAlex.
- CKS1B as Drug Resistance-Inducing Gene-A Potential Target to Improve Cancer Therapy.Frontiers in oncology · 2020Review
- The Prozone Effect Accounts for the Paradoxical Function of the Cdk-Binding Protein Suc1/Cks.Cell reports · 2016Article
- Loss of cks1 homeostasis deregulates cell division cycle.Journal of cellular and molecular medicine · 2010Review
- A pcl-like cyclin activates the Res2p-Cdc10p cell cycle "start" transcriptional factor complex in fission yeast.Molecular biology of the cell · 2000Article
- Ectopic expression of cdc2/cdc28 kinase subunit Homo sapiens 1 uncouples cyclin B metabolism from the mitotic spindle cell cycle checkpoint.Molecular and cellular biology · 1998Article
- Xe-p9, a Xenopus Suc1/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase- promoting complex at mitosis.Genes & development · 1998Article
- Cyclin-stimulated binding of Cks proteins to cyclin-dependent kinases.Molecular and cellular biology · 1998Article
- A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2/B-type cyclin complexes.Molecular biology of the cell · 1997Article
- Is the yeast anaphase promoting complex needed to prevent re-replication during G2 and M phases?The EMBO journal · 1997Article
- Modeling the control of DNA replication in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- p25rum1 promotes proteolysis of the mitotic B-cyclin p56cdc13 during G1 of the fission yeast cell cycle.The EMBO journal · 1997Article
- Fission yeast pheromone blocks S-phase by inhibiting the G1 cyclin B-p34cdc2 kinase.The EMBO journal · 1997Article
- B-type cyclins regulate G1 progression in fission yeast in opposition to the p25rum1 cdk inhibitor.The EMBO journal · 1996Article
- A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins.The EMBO journal · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
suc1 is an essential gene initially identified for its ability to rescue certain temperature-sensitive alleles of cdc2 in Schizosaccharomyces pombe. The role of suc1 in the regulation of the cdc2 kinase is not well understood. In our study, we have characterized the biochemical effect of loss of suc1 function on specific cdc2-cyclin complexes. We show that the cig1 cyclin is associated with cdc2 and that the cdc2-cig1 kinase is activated at mitosis, with kinetics similar to those of the cdc2-cdc13 kinase. We provide evidence that loss of suc1 function affects the kinase activity of the two distinct mitotic forms of the cdc2 kinase. We also show that a dramatic increase in the level of the cdc13 protein is associated with loss of suc1. These results suggest that mitosis cannot be properly completed in the absence of suc1, possibly because of an increase in the level of cdc2-cdc13 complex, and support the idea of a role for suc1 in the regulation of multiple forms of the cdc2 kinase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.