ArticleMolecular and cellular biology1995
Mitotic regulation of a TATA-binding-protein-containing complex.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 102 citations in OpenAlex.
- Transcriptional repression across mitosis: mechanisms and functions.Biochemical Society transactions · 2024Review
- Cell Cycle-Dependent Transcription: The Cyclin Dependent Kinase Cdk1 Is a Direct Regulator of Basal Transcription Machineries.International journal of molecular sciences · 2022Review
- ROS Signaling-Mediated Novel Biological Targets: Brf1 and RNA Pol III Genes.Oxidative medicine and cellular longevity · 2021Review
- Coupling of RNA polymerase III assembly to cell cycle progression in Saccharomyces cerevisiae.Cell cycle (Georgetown, Tex.) · 2019Article
- Imaging RNA polymerase III transcription using a photostable RNA-fluorophore complex.Nature chemical biology · 2017Article
- Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription.Cell cycle (Georgetown, Tex.) · 2010Review
- Regulation of TFIIIB during F9 cell differentiation.BMC molecular biology · 2010Article
- Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells.Nucleic acids research · 2010Article
- Mitotic bookmarking of formerly active genes: keeping epigenetic memories from fading.Cell cycle (Georgetown, Tex.) · 2009Article
- Facilitated recycling protects human RNA polymerase III from repression by Maf1 in vitro.The Journal of biological chemistry · 2008Article
- Recruitment of RNA polymerase III in vivo.Nucleic acids research · 2008Article
- PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex.Molecular and cellular biology · 2008Article
- TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- RNA polymerase III transcription is repressed in response to the tumour suppressor ARF.Nucleic acids research · 2007Article
- Regulation of RNA polymerase III transcription during hypertrophic growth.The EMBO journal · 2006Article
- Hypoxic stress suppresses RNA polymerase III recruitment and tRNA gene transcription in cardiomyocytes.Nucleic acids research · 2006Article
- A test of the model that RNA polymerase III transcription is regulated by selective induction of the 110 kDa subunit of TFIIIC.Nucleic acids research · 2006Article
- Human La is found at RNA polymerase III-transcribed genes in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Deregulation of RNA polymerase III transcription in cervical epithelium in response to high-risk human papillomavirus.Oncogene · 2005Article
- TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo.The EMBO journal · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The mitotic state is associated with a generalized repression of transcription. We show that mitotic repression of RNA polymerase III transcription can be reproduced by using extracts of synchronized HeLa cells. We have used this system to investigate the molecular basis of transcriptional repression during mitosis. We find a specific decrease in the activity of the TATA-binding-protein (TBP)-containing complex TFIIIB. TBP itself is hyperphosphorylated at mitosis, but this does not appear to account for the loss of TFIIIB activity. Instead, one or more TBP-associated components appear to be regulated. The data suggest that changes in the activity of TBP-associated components contribute to the coordinate repression of gene expression that occurs at mitosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.