ArticleMolecular and cellular biology1995
Synergistic interactions between heterologous upstream activation elements and specific TATA sequences in a muscle-specific promoter.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Article
- Integration of RNA-seq and ATAC-seq identifies muscle-regulated hub genes in cattle.Frontiers in veterinary science · 2022Article
- The New Model of Snail Expression Regulation: The Role of MRTFs in Fast and Slow Endothelial-Mesenchymal Transition.International journal of molecular sciences · 2020Article
- Severe myopathy in mice lacking the MEF2/SRF-dependent gene leiomodin-3.The Journal of clinical investigation · 2015Article
- Article
- Regulation of myoglobin expression.The Journal of experimental biology · 2010Review
- Calcineurin activates cytoglobin transcription in hypoxic myocytes.The Journal of biological chemistry · 2009Article
- Hypoxia reprograms calcium signaling and regulates myoglobin expression.American journal of physiology. Cell physiology · 2009Article
- Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity.The Journal of clinical investigation · 2007Article
- Transcription enhancer factor 1 binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions.Molecular and cellular biology · 2003Article
- MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type.The EMBO journal · 2000Article
- The winged-helix/forkhead protein myocyte nuclear factor beta (MNF-beta) forms a co-repressor complex with mammalian sin3B.The Biochemical journal · 2000Article
- Article
- Fiber-type-specific transcription of the troponin I slow gene is regulated by multiple elements.Molecular and cellular biology · 1999Article
- A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type.Genes & development · 1998Article
- TFII-I regulates Vbeta promoter activity through an initiator element.Molecular and cellular biology · 1998Article
- In vivo protein binding and functional analysis of cis-acting elements in the U3 region of the bovine leukemia virus long terminal repeat.Journal of virology · 1998Article
- Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis.The Journal of cell biology · 1997Article
- Transient expression of a winged-helix protein, MNF-beta, during myogenesis.Molecular and cellular biology · 1997Article
- A minimal regulatory region maintains constitutive expression of the max gene.Molecular and cellular biology · 1997Article
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Authors and funding
4 authors.
Funding
Abstract
Previous investigations have defined three upstream activation elements--CCAC, A/T, and TATA sequences--necessary for muscle-specific transcription of the myoglobin gene. In the present study, we demonstrate that these three sequences elements, prepared as synthetic oligonucleotide cassettes, function synergistically to constitute a cell-type-specific transcription unit. Previously, cognate binding factors that recognize the CCAC and TATA elements were identified. In this study we determine that the A/T element binds two nuclear factors, including myocyte enhancer factor-2 (MEF-2) and an apparently unknown factor we provisionally termed ATF35 (A/T-binding factor, 35 kDa). Mutations that alter in vitro binding of either MEF-2 or ATF35 to this site diminish promoter function in vivo. Functional synergism between factors binding the CCAC and A/T elements is sensitive to subtle mutations in the TATA sequence, recapitulating the unusual preference for specific TATA variants exhibited by the native myoglobin promoter. These results provide new insights into mechanisms that underlie the distinctive pattern of myoglobin gene regulation in mammalian muscle development and lay a foundation for further studies to elucidate general principles of transcriptional control of complex mammalian promoters through combinatorial actions of heterologous transcriptional factors.
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