ArticleInfection and immunity1995
Isolation and identification of a glutathione peroxidase homolog gene, gpxA, present in Neisseria meningitidis but absent in Neisseria gonorrhoeae.
Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- Article
- Destroying glutathione peroxidase improves the oxidative stress resistance and pathogenicity ofFrontiers in microbiology · 2023Article
- The Central Role of Redox-Regulated Switch Proteins in Bacteria.Frontiers in molecular biosciences · 2021Review
- Mechanisms of group A Streptococcus resistance to reactive oxygen species.FEMS microbiology reviews · 2015Review
- Towards New Drug Targets? Function Prediction of Putative Proteins of Neisseria meningitidis MC58 and Their Virulence Characterization.Omics : a journal of integrative biology · 2015Article
- Article
- The Escherichia coli btuE gene, encodes a glutathione peroxidase that is induced under oxidative stress conditions.Biochemical and biophysical research communications · 2010Article
- Overproduction or absence of the periplasmic protease DegP severely compromises bacterial growth in the absence of the dithiol: disulfide oxidoreductase DsbA.Molecular & cellular proteomics : MCP · 2008Article
- Defenses against oxidative stress in Neisseria gonorrhoeae: a system tailored for a challenging environment.Microbiology and molecular biology reviews : MMBR · 2006Review
- Isolation of a chromosomal region of Klebsiella pneumoniae associated with allantoin metabolism and liver infection.Infection and immunity · 2004Article
- Contribution of glutathione peroxidase to the virulence of Streptococcus pyogenes.Infection and immunity · 2004Article
- exl, an exchangeable genetic island in Neisseria meningitidis.Infection and immunity · 2001Article
- Molecular and biological analysis of eight genetic islands that distinguish Neisseria meningitidis from the closely related pathogen Neisseria gonorrhoeae.Infection and immunity · 2000Article
- Role of oxidants in microbial pathophysiology.Clinical microbiology reviews · 1997Review
- Analysis of the genetic differences between Neisseria meningitidis and Neisseria gonorrhoeae: two closely related bacteria expressing two different pathogenicities.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Interruption of the gpxA gene increases the sensitivity of Neisseria meningitidis to paraquat.Journal of bacteriology · 1996Article
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2 authors.
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Abstract
Antioxidant enzymes are thought to be important for the survival of pathogenic Neisseria species. We isolated a glutathione peroxidase-related gene (gpxA) from Neisseria meningitidis FAM20. The N. meningitidis glutathione peroxidase homolog was 49 to 57% identical to seven other glutathione peroxidase family members over a 49-amino-acid region which is conserved among various species. The gpxA sequence was present in all 7 meningococcal strains tested but absent in 10 gonococcal strains and 6 nonpathogenic neisserial strains as determined by Southern hybridization. The homology of gpxA to mammalian glutathione peroxidases and the presence of this gene specifically in the meningococcus suggest that it is important in the cellular metabolism or defense processes particular to this pathogen.
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