ArticleInfection and immunity1995
Cloning and sequence analysis of a protective M-like protein gene from Streptococcus equi subsp. zooepidemicus.
Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Streptococcal infections in cats: ABCD guidelines on prevention and management.Journal of feline medicine and surgery · 2015Guideline
- Molecular determinants of pathogenicity in a Streptococcus equi subsp. zooepidemicus strain from wild boar in Russia.Molecular genetics and genomics : MGG · 2026Article
- A zoonoticInfection and immunity · 2026Article
- The P124A mutation of SRP14 alters its migration on SDS-PAGE without impacting its function.Acta biochimica et biophysica Sinica · 2024Article
- Endogenous Type I-C CRISPR-Cas system ofFrontiers in microbiology · 2024Article
- A distinct variant of the SzM protein ofVirulence · 2023Article
- Streptococcus equi subspecies zooepidemicus - a case report of sudden death in a German sow farm.Porcine health management · 2023Article
- A streptococcal Fic domain-containing protein disrupts blood-brain barrier integrity by activating moesin in endothelial cells.PLoS pathogens · 2019Article
- Genetics and Pathogenicity Factors of Group C and G Streptococci.Microbiology spectrum · 2019Review
- Outbreak of Glomerulonephritis Caused by Streptococcus zooepidemicus SzPHV5 Type in Monte Santo de Minas, Minas Gerais, Brazil.Journal of clinical microbiology · 2018Article
- Streptococcus equi subspecies zooepidemicus septicemia in alpacas: three cases and review of the literature.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2018Article
- Article
- Characterization and protective immunogenicity of the SzM protein of Streptococcus zooepidemicus NC78 from a clonal outbreak of equine respiratory disease.Clinical and vaccine immunology : CVI · 2013Article
- Interaction between M-like protein and macrophage thioredoxin facilitates antiphagocytosis for Streptococcus equi ssp. zooepidemicus.PloS one · 2012Article
- Article
- Streptococcus zooepidemicus: an emerging canine pathogen.Veterinary journal (London, England : 1997) · 2011Review
- Determination of the mimic epitope of the M-like protein adhesin in swine Streptococcus equi subsp. zooepidemicus.BMC microbiology · 2008Article
- Contribution of the alanine-rich region of Streptococcus mutans P1 to antigenicity, surface expression, and interaction with the proline-rich repeat domain.Infection and immunity · 2004Article
- Analysis of immunoreactivity to a Streptococcus equi subsp. zooepidemicus M-like protein To confirm an outbreak of poststreptococcal glomerulonephritis, and sequences of M-like proteins from isolates obtained from different host species.Journal of clinical microbiology · 2000Article
- Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope.Microbiology and molecular biology reviews : MMBR · 1999Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus equi subsp. zooepidemicus, a Lancefield group C streptococcus, is a frequently isolated opportunist pathogen from a variety of animal hosts, including the horse. Previous studies have indicated that equine strains carry antigens with characteristics of the antiphagocytic M proteins on the Lancefield groups A and G streptococci. We have cloned a protective M-like protein gene (SzPW60) of an equine strain of S. equi subsp. zooepidemicus W60 and determined its sequence. This gene encodes a protein with a molecular weight of 40,123 which protects mice against subsp. zooepidemicus but not subsp. equi, stimulates antibodies which opsonize subsp. zooepidemicus but not equi, and reacts with antiserum to the protein of the parent strain. The predicted amino acid structure shows significant homology with the carboxy termini of groups A and G M proteins but no other homology. The M-like protein, although showing an extensive region of alpha helix, lacks the A, B, and C repeats found in group A M proteins and has a shorter signal sequence. A proline-rich region upstream from the LPSTGE motif contains 20 repeats of the tetrapeptide PEPK. The presence of this repeat region may account for the slow migration of the M-like protein in sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
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