ArticleInfection and immunity1995
Expression of surface hydrophobic proteins by Candida albicans in vivo.
Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 68 citations in OpenAlex.
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- Fungi-A Component of the Oral Microbiome Involved in Periodontal Diseases.Advances in experimental medicine and biology · 2022Article
- Optimal Design of THEDES Based on Perillyl Alcohol and Ibuprofen.Pharmaceutics · 2020Article
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- Effect of pepstatin A on the virulence factors of Candida albicans strains isolated from vaginal environment of patients in three different clinical conditions.Mycopathologia · 2006Article
- Cloning and analysis of a Candida albicans gene that affects cell surface hydrophobicity.Journal of bacteriology · 2001Article
- Inhibition of hydrophobic protein-mediated Candida albicans attachment to endothelial cells during physiologic shear flow.Infection and immunity · 2001Article
- New assay for measuring cell surface hydrophobicities of Candida dubliniensis and Candida albicans.Clinical and diagnostic laboratory immunology · 2001Article
- Comparison of the hydrophobic properties of Candida albicans and Candida dubliniensis.Infection and immunity · 2001Article
- Coaggregation of Candida dubliniensis with Fusobacterium nucleatum.Journal of clinical microbiology · 1999Article
- Cell wall and secreted proteins of Candida albicans: identification, function, and expression.Microbiology and molecular biology reviews : MMBR · 1998Review
- Evidence for presence in the cell wall of Candida albicans of a protein related to the hsp70 family.Infection and immunity · 1996Article
- Common and form-specific cell wall antigens of Candida albicans as released by chemical and enzymatic treatments.Mycopathologia · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Candida albicans modulates cell surface hydrophobicity during growth and morphogenesis in vitro. To determine if surface hydrophobicity is expressed during pathogenesis, we generated a polyclonal antiserum against yeast hydrophobic proteins. The antiserum was then used for indirect immunofluorescence analysis of tissues from mice colonized and chronically infected with C. albicans. Results demonstrated that yeast hydrophobic proteins are exposed on fungal cells present in host tissues. The polyclonal antiserum distinguished between hydrophobic and hydrophilic cell surfaces in vitro and gave similar staining patterns and intensities for C. albicans cells in vivo. Of the yeast forms present within tissue lesions, approximately half exhibited moderate to intense immunofluorescence with the antiserum. Immunoblot analysis indicated that antigens recognized by the antiserum are predominantly low-molecular-mass hydrophobic proteins that are expressed by different C. albicans isolates and are expressed regardless of growth temperature. Taken together, the immunofluorescence and immunoblot analyses of antigens indicate that C. albicans displays surface hydrophobic proteins during pathogenesis and these proteins are available for hydrophobic interactions with host tissues. The effect of hydrophobic protein exposure on the virulence of C. albicans is discussed.
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