ArticleImmunogenetics1995
Association of H2Ab with resistance to collagen-induced arthritis in H2-recombinant mouse strains: an allele associated with reduction of several apparently unrelated responses.
Article in Immunogenetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseases.Arthritis research & therapy · 2004Review
- Recessive expression of the H2A-controlled immune response phenotype depends critically on antigen dose.Immunology · 2000Article
- Natural and induced regulation of Th1/Th2 balance.Springer seminars in immunopathology · 1999Review
- Bystander suppression of murine collagen-induced arthritis by long-term nasal administration of a self type II collagen peptide.Clinical and experimental immunology · 1998Article
- Differential expression of major histocompatibility complex class II genes on murine macrophages associated with T cell cytokine profile and protective/suppressive effects.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- The importance of the back-signal from T cells into antigen-presenting cells in determining susceptibility to parasites.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1997Review
- Third International Workshop on Reactive Arthritis. 23-26 September 1995, Berlin, Germany. Report and abstracts.Annals of the rheumatic diseases · 1996Article
- H2-A polymorphism contributes to H2-Ebeta-mediated protection in collagen-induced arthritis.Immunogenetics · 1996Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HLA class II alleles can protect against immunological diseases. Seeking an animal model for a naturally occurring protective allele, we screened a panel of H2-congenic and recombinant mouse strains for ability to protect against collagen-induced arthritis. The strains were crossed with the susceptible strain DBA/1, and the F1 hybrids immunized with cattle and chicken type II collagen. Hybrids having the H2Ab allele displayed a reduced incidence and duration of the disease. They also had a reduced level of pre-disease inflammation, but not of anti-collagen antibodies. The allele is already known to be associated with reduction of other apparently unrelated immune responses, suggesting that some form of functional differentiation may operate that is not exclusively related to epitope-binding. It is suggested that this may reflect allelic variation in the class II major histocompatibility complex promoter region.
Indexed as
Identifiers
7890326What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.