ArticleImmunology1995
Tumour necrosis factor-alpha is required for accumulation of dendritic cells in draining lymph nodes and for optimal contact sensitization.
Article in Immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 247 citations in OpenAlex.
- IL-1beta-induced Langerhans' cell migration and TNF-alpha production in human skin: regulation by lactoferrin.Clinical and experimental immunology · 2003Trial
- Immune responses to human papillomavirus infection and vaccination.Frontiers in immunology · 2025Review
- Beyond Avoidance: Advanced Therapies for Contact Dermatitis.The journal of allergy and clinical immunology. In practice · 2024Review
- A short-term high-sugar diet is an aggravating factor in experimental allergic contact dermatitis.Heliyon · 2023Article
- Occupational Skin Dermatitis among Healthcare Workers Associated with the COVID-19 Pandemic: A Review of the Literature.International journal of molecular sciences · 2023Review
- In Sickness and in Health: The Immunological Roles of the Lymphatic System.International journal of molecular sciences · 2021Review
- Review
- HMGB1-mediated chromatin remodeling attenuatesProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Piperine Ameliorates Trimellitic Anhydride-Induced Atopic Dermatitis-Like Symptoms by Suppressing Th2-Mediated Immune Responses via Inhibition of STAT6 Phosphorylation.Molecules (Basel, Switzerland) · 2020Article
- Uncovering the Mysteries of Langerhans Cells, Inflammatory Dendritic Epidermal Cells, and Monocyte-Derived Langerhans Cell-Like Cells in the Epidermis.Frontiers in immunology · 2018Review
- Epidermal PPARγ influences subcutaneous tumor growth and acts through TNF-α to regulate contact hypersensitivity and the acute photoresponse.Oncotarget · 2017Article
- Immunosuppressive effects of Amblyomma cajennense tick saliva on murine bone marrow-derived dendritic cells.Parasites & vectors · 2015Article
- Skin sensitization induced Langerhans' cell mobilization: variable requirements for tumour necrosis factor-α.Immunology · 2015Article
- Hapten-induced contact hypersensitivity, autoimmune reactions, and tumor regression: plausibility of mediating antitumor immunity.Journal of immunology research · 2014Review
- Mechanisms by which chronic ethanol feeding impairs the migratory capacity of cutaneous dendritic cells.Alcoholism, clinical and experimental research · 2013Article
- Age-related Dysregulation of Inflammation and Innate Immunity: Lessons Learned from Rodent Models.Aging and disease · 2011Article
- B cells are critical to T-cell-mediated antitumor immunity induced by a combined immune-stimulatory/conditionally cytotoxic therapy for glioblastoma.Neoplasia (New York, N.Y.) · 2011Article
- Aging of the Innate Immune System: An Update.Current immunology reviews · 2011Article
- Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II.Nature immunology · 2010Article
- Mechanisms and consequences of dendritic cell migration.Immunity · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Following skin sensitization epidermal Langerhans' cells (LC), many of which bear antigen, are stimulated to migrate from the skin and traffic via afferent lymphatics to lymph nodes draining the site of exposure. It has been proposed previously that tumour necrosis factor-alpha (TNF-alpha), a keratinocyte-derived epidermal cytokine (the expression of which is augmented following cutaneous sensitization), provides one signal for LC migration. In the experiments described here the influence of systemically administered neutralizing anti-TNF-alpha antibody on dendritic cell (DC) accumulation in draining lymph nodes has been investigated. Treatment with anti-TNF-alpha inhibited markedly the frequency of DC in draining nodes measured 18 hr following exposure to the skin allergens oxazolone and fluorescein isothiocyanate or to the non-sensitizing skin irritant sodium lauryl sulphate. Similar treatment with anti-TNF-alpha 2 hr prior to primary exposure to oxazolone impaired significantly the efficiency of skin sensitization measured 5 days later as a function of challenge-induced increases in ear thickness. The same antibody administered 18 hr following initial exposure to oxazolone was without effect on skin sensitization. These data confirm the importance of TNF-alpha for the migration of LC from the skin to draining lymph nodes and demonstrate that this cytokine is required for optimal contact sensitization.
Indexed as
Identifiers
7890303PMC1415198W21346515What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.