ArticleImmunology1995
Serotonin regulation of T-cell subpopulations and of macrophage accessory function.
Article in Immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01650311 (Investigating Serotonin Signalling in IBD Patients), which is not on this map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating Serotonin Signalling in IBD Patients
Who cites it
25 citing papers in PubMed, 90 citations in OpenAlex.
- Imipramine Administration inPharmaceuticals (Basel, Switzerland) · 2023Article
- Antidepressants and the Risk of Psoriasis Induction: A Case-Control Study.Advanced biomedical research · 2023Article
- Selective serotonin reuptake inhibitors and inflammatory bowel disease; Beneficial or malpractice.Frontiers in immunology · 2022Review
- Antitumor Effect of Fluoxetine on Chronic Stress-Promoted Lung Cancer Growth via Suppressing Kynurenine Pathway and Enhancing Cellular Immunity.Frontiers in pharmacology · 2021Article
- Harman and norharman, metabolites of the entomopathogenic fungusCell & bioscience · 2019Article
- Modulation of the immune response by helminths: a role for serotonin?Bioscience reports · 2018Review
- Posttraumatic Stress Disorder: An Immunological Disorder?Frontiers in psychiatry · 2017Review
- The Effects of Serotonin in Immune Cells.Frontiers in cardiovascular medicine · 2017Review
- Immunohistochemical Evaluation of Role of Serotonin in Pathogenesis of Psoriasis.Journal of clinical and diagnostic research : JCDR · 2016Article
- Antidepressant imipramine diminishes stress-induced inflammation in the periphery and central nervous system and related anxiety- and depressive- like behaviors.Brain, behavior, and immunity · 2016Article
- Effects of ketanserin on experimental colitis in mice and macrophage function.International journal of molecular medicine · 2016Article
- A human and animal model-based approach to investigating the anti-inflammatory profile and potential of the 5-HT2B receptor antagonist AM1030.Journal of inflammation (London, England) · 2016Article
- PTSD, a Disorder with an Immunological Component.Frontiers in immunology · 2016Review
- Serotonin Receptor Agonist 5-Nonyloxytryptamine Alters the Kinetics of Reovirus Cell Entry.Journal of virology · 2015Article
- Immunomodulatory effects mediated by serotonin.Journal of immunology research · 2015Review
- A dialogue between the immune system and brain, spoken in the language of serotonin.ACS chemical neuroscience · 2013Review
- Serotonergic chemosensory neurons modify the C. elegans immune response by regulating G-protein signaling in epithelial cells.PLoS pathogens · 2013Article
- Psychotropic effects of antimicrobials and immune modulation by psychotropics: implications for neuroimmune disorders.Neuropsychiatry · 2012Article
- Novel identified receptors on mast cells.Frontiers in immunology · 2012Article
- Selective serotonin reuptake inhibitor suppression of HIV infectivity and replication.Psychosomatic medicine · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The role of serotonin as an immune modulator was investigated by measuring the functional competence of T cells from control mice versus from mice whose intracellular stores of serotonin had been depleted by pretreatment with p-chlorophenylalanine (PCPA). While the proportions of splenic CD4+ and CD8+ T cells isolated from control and PCPA-treated mice were similar, the level of expression of the alpha-chain interleukin-2 receptor (IL-2R) was reduced on splenic CD4+ cells but not on CD8+ cells. Culture with the T-cell mitogen concanavalin A (Con A) failed to induce expression of the IL-2R on either CD4+ or CD8+ cells of PCPA-treated mice, although IL-2R was induced on control cells. The proliferative response to Con A by these spleen cells from PCPA-treated mice was also reduced compared to that by control spleen cells. Both expression of IL-2R and proliferation in response to Con A by spleen cells from serotonin-depleted mice were increased or completely restored by supplementation of the cultures with serotonin. Studies to identify the mechanisms for the reduction in T-cell activation when serotonin levels were reduced implicated a defect in the capacity of macrophages from PCPA-treated mice to provide accessory help for T-cell activation. Splenic macrophages from control mice were able to restore the blastogenic capability of lymphocytes from PCPA-treated mice, although macrophages from PCPA-treated mice were unable to support normal lymphocyte blastogenesis unless the cultures were supplemented with serotonin. These results show the requirement of autologous serotonin for optimal T-cell activation and suggest the importance of serotonin in macrophage accessory function for T-cell activation.
Indexed as
Identifiers
7890297PMC1415171W2406894639What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.