ArticleThe EMBO journal1995
Chromosome condensation induced by fostriecin does not require p34cdc2 kinase activity and histone H1 hyperphosphorylation, but is associated with enhanced histone H2A and H3 phosphorylation.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 154 citations in OpenAlex.
- Phase I and pharmacokinetic study of fostriecin given as an intravenous bolus daily for five consecutive days.Investigational new drugs · 2004Trial
- Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin.British journal of cancer · 1999Trial
- Formal Synthesis of Fostriecin via Asymmetric Alcohol-Mediated Carbonyl Allylation.Organic letters · 2025Article
- Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulators.Molecular biology of the cell · 2022Article
- Total and Formal Syntheses of Fostriecin.Organic chemistry frontiers : an international journal of organic chemistry · 2020Article
- Allyl-Isothiocyanate and Microcystin-LR Reveal the Protein Phosphatase Mediated Regulation of Metaphase-Anaphase Transition inFrontiers in plant science · 2018Article
- Synthetic Strategies Employed for the Construction of Fostriecin and Related Natural Products.Chemical reviews · 2016Review
- Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERRβ2) splice variant in breast cancer.Oncotarget · 2016Article
- Specific threonine-4 phosphorylation and function of RNA polymerase II CTD during M phase progression.Scientific reports · 2016Article
- Novel insights into mitotic chromosome condensation.F1000Research · 2016Review
- ERRβ splice variants differentially regulate cell cycle progression.Cell cycle (Georgetown, Tex.) · 2015Article
- Methylseleninic acid suppresses pancreatic cancer growth involving multiple pathways.Nutrition and cancer · 2014Article
- Lasonolide A, a potent and reversible inducer of chromosome condensation.Cell cycle (Georgetown, Tex.) · 2012Article
- Microcystin-LR, a protein phosphatase inhibitor, induces alterations in mitotic chromatin and microtubule organization leading to the formation of micronuclei in Vicia faba.Annals of botany · 2012Article
- Functional dicer is necessary for appropriate specification of radial glia during early development of mouse telencephalon.PloS one · 2011Article
- Inhibiting MAP kinase activity prevents calcium transients and mitosis entry in early sea urchin embryos.The Journal of biological chemistry · 2005Article
- The H1 phosphorylation state regulates expression of CDC2 and other genes in response to starvation in Tetrahymena thermophila.Molecular and cellular biology · 2005Article
- The enhancement of histone H4 and H2A serine 1 phosphorylation during mitosis and S-phase is evolutionarily conserved.Chromosoma · 2004Article
- Article
- Protein phosphatase 2A activity affects histone H3 phosphorylation and transcription in Drosophila melanogaster.Molecular and cellular biology · 2003Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Chromosome condensation at mitosis correlates with the activation of p34cdc2 kinase, the hyperphosphorylation of histone H1 and the phosphorylation of histone H3. Chromosome condensation can also be induced by treating interphase cells with the protein phosphatase 1 and 2A inhibitors okadaic acid and fostriecin. Mouse mammary tumour FT210 cells grow normally at 32 degrees C, but at 39 degrees C they lose p34cdc2 kinase activity and arrest in G2 because of a temperature-sensitive lesion in the cdc2 gene. The treatment of these G2-arrested FT210 cells with fostriecin or okadaic acid resulted in full chromosome condensation in the absence of p34cdc2 kinase activity or histone H1 hyperphosphorylation. However, phosphorylation of histones H2A and H3 was strongly stimulated, partly through inhibition of histone H2A and H3 phosphatases, and cyclins A and B were degraded. The cells were unable to complete mitosis and divide. In the presence of the protein kinase inhibitor starosporine, the addition of fostriecin did not induce histone phosphorylation and chromosome condensation. The results show that chromosome condensation can take place without either the histone H1 hyperphosphorylation or the p34cdc2 kinase activity normally associated with mitosis, although it requires a staurosporine-sensitive protein kinase activity. The results further suggest that protein phosphatases 1 and 2A may be important in regulating chromosome condensation by restricting the level of histone phosphorylation during interphase, thereby preventing premature chromosome condensation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.