Trial reportBMJ (Clinical research ed.)1995
Randomised trial of lipid lowering dietary advice in general practice: the effects on serum lipids, lipoproteins, and antioxidants.
Trial report in BMJ (Clinical research ed.), 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 14 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 14 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Pooled it
- Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020Pooled it
- Effects of total fat intake on body fatness in adults.The Cochrane database of systematic reviews · 2020Pooled it
- Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020Pooled it
- Effectiveness of dietetic consultation for lowering blood lipid levels in the management of cardiovascular disease risk: A systematic review and meta-analysis of randomised controlled trials.Nutrition & dietetics : the journal of the Dietitians Association of Australia · 2019Pooled it
- Effects of total fat intake on body weight.The Cochrane database of systematic reviews · 2015Pooled it
- Dietary interventions (plant sterols, stanols, omega-3 fatty acids, soy protein and dietary fibers) for familial hypercholesterolaemia.The Cochrane database of systematic reviews · 2014Pooled it
- Dietary advice for reducing cardiovascular risk.The Cochrane database of systematic reviews · 2013Pooled it
- Nurse delivered lifestyle interventions in primary health care to treat chronic disease risk factors associated with obesity: a systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2012Pooled it
- Reduced or modified dietary fat for preventing cardiovascular disease.The Cochrane database of systematic reviews · 2012Pooled it
- Reduced or modified dietary fat for preventing cardiovascular disease.The Cochrane database of systematic reviews · 2011Pooled it
- Dietary advice given by a dietitian versus other health professional or self-help resources to reduce blood cholesterol.The Cochrane database of systematic reviews · 2001Pooled it
- Joint British recommendations on prevention of coronary heart disease in clinical practice. British Cardiac Society, British Hyperlipidaemia Association, British Hypertension Society, endorsed by the British Diabetic Association.Heart (British Cardiac Society) · 1998Guideline
- Systematic review of dietary intervention trials to lower blood total cholesterol in free-living subjects.BMJ (Clinical research ed.) · 1998Pooled it
- Effectiveness of Written Dietary Advice for Improving Blood Lipids in Primary Care Adults-A Pragmatic Randomized Controlled Trial (MYDICLIN).Nutrients · 2022Trial
- The effectiveness of a primary care nursing-led dietary intervention for prediabetes: a mixed methods pilot study.BMC family practice · 2017Trial
- The effect of credibility-related design cues on responses to a web-based message about the breast cancer risks from alcohol: randomized controlled trial.Journal of medical Internet research · 2009Trial
- A transferable programme of nutritional counselling for rehabilitation following myocardial infarction: a randomised controlled study.European journal of clinical nutrition · 2004Trial
- Nutritional counselling in general practice: a cost effective analysis.Journal of epidemiology and community health · 1999Trial
- The validity of dietary assessment in general practice.Journal of epidemiology and community health · 1999Trial
Corrections and comments
- Commented on by
Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the relative efficacy in general practice of dietary advice given by a dietitian, a practice nurse, or a diet leaflet alone in reducing total and low density lipoprotein cholesterol concentration.
designRandomised six month parallel trial.
settingA general practice in Oxfordshire. SUBJECTS: 2004 subjects aged 35-64 years were screened for hypercholesterolaemia; 163 men and 146 women with a repeat total cholesterol concentration of 6.0-8.5 mmol/l entered the trial.
interventionsIndividual advice provided by a dietitian using a diet history, a practice nurse using a structured food frequency questionnaire, or a detailed diet leaflet sent by post. All three groups were advised to limit the energy provided by fat to 30% or less and to increase carbohydrate and dietary fibre.
main outcome measuresConcentrations of total cholesterol and low density and high density lipoprotein cholesterol after six months; antioxidant concentration and body mass index.
resultsNo significant differences were found at the end of the trial between groups in mean concentrations of lipids, lipoproteins, and antioxidants or body mass index. After data were pooled from the three groups, the mean total cholesterol concentration fell by 1.9% (0.13 mmol/l, 95% confidence interval 0.06 to 0.22, P < 0.001) to 7.00 mmol/l, and low density lipoprotein cholesterol also fell. The total carotenoid concentration increased by 53 nmol/l (95% confidence interval 3.0 to 103, P = 0.039).
conclusionsDietary advice is equally effective when given by a dietitian, a practice nurse, or a diet leaflet alone but results in only a small reduction in total and low density lipoprotein cholesterol. To obtain a better response more intensive intervention than is normally available in primary care is probably necessary.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.