ArticleParasitology research1994
The behavior and pathogenicity of Toxacara canis larvae in mice of different strains.
Article in Parasitology research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Who Let the Dogs Out? Unmasking the Neglected: A Semi-Systematic Review on the Enduring Impact of Toxocariasis, a Prevalent Zoonotic Infection.International journal of environmental research and public health · 2023Review
- Larva migrans in BALB/c mice experimentally infected with Toxocara cati ensured by PCR assay.BMC veterinary research · 2022Article
- Mechanisms of the host immune response and helminth-induced pathology during Trichobilharzia regenti (Schistosomatidae) neuroinvasion in mice.PLoS pathogens · 2022Article
- Article
- Brain food: rethinking food-borne toxocariasis.Parasitology · 2022Review
- Case-Control Study to Assess the Association between Epilepsy andMicroorganisms · 2021Article
- "Begging the Question"-DoesPathogens (Basel, Switzerland) · 2020Article
- Article
- Parasites in brains of wild rodents (Arvicolinae and Murinae) in the city of Leipzig, Germany.International journal for parasitology. Parasites and wildlife · 2019Article
- Histopathological characterization of Toxocara canis- and T. cati-induced neurotoxocarosis in the mouse model.Parasitology research · 2019Article
- Neuroinvasion of Toxocara canis- and T. cati-larvae mediates dynamic changes in brain cytokine and chemokine profile.Journal of neuroinflammation · 2019Article
- Abnormal neurobehaviour and impaired memory function as a consequence of Toxocara canis- as well as Toxocara cati-induced neurotoxocarosis.PLoS neglected tropical diseases · 2017Article
- Experimental toxocariasis in BALB/c mice: relationship between parasite inoculum and the IgG immune response.Memorias do Instituto Oswaldo Cruz · 2017Article
- An alternative method for producing Toxocara canis second stage larvae from a paratenic host (pigeon) for mRNA extraction purpose.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2015Article
- Neurotoxocarosis alters myelin protein gene transcription and expression.Parasitology research · 2015Article
- Neurotoxocarosis: marked preference of Toxocara canis for the cerebrum and T. cati for the cerebellum in the paratenic model host mouse.Parasites & vectors · 2014Article
- Toxocara canis larvae reinfecting BALB/c mice exhibit accelerated speed of migration to the host CNS.Parasitology research · 2011Article
- Brain injury-associated biomarkers of TGF-beta1, S100B, GFAP, NF-L, tTG, AbetaPP, and tau were concomitantly enhanced and the UPS was impaired during acute brain injury caused by Toxocara canis in mice.BMC infectious diseases · 2008Article
- Enhanced expression of transforming growth factor-beta1 in inflammatory cells and secretory granules in Paneth cells in the small intestine of mice infected with Toxocara canis.Parasitology research · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study the behavior and pathogenicity of second-stage larvae of Toxocara canis were examined in different mouse strains with special emphasis on the major histocompatibility complex (MHC). Mice of the inbred strains BALB, C3H, C57BL, and DBA and the outbred strain NMRI were infected orally with 1000 second-stage larvae of T. canis. The clinical behavior of the animals; the numbers of larvae detected in the liver, lungs, brain, and musculature; the hematological and serological parameters; and histological sections were examined. In mice of the BALB strain, no death occurred during the entire period of the investigation and the pattern of body-weight development of infected and uninfected animals was almost identical. The highest larval counts in the brain of all strains were found in BALB mice. The percentage of eosinophils in the blood of BALB mice increased after the 8th week postinfection, whereas it decreased in the other strains. Histological and pathophysiological changes developed to a lesser extent in this strain than in the other strains. In mice of the strains C3H, C57BL, DBA, and NMRI, deaths occurred from the 4th week postinfection onward. The infected animals lost weight in comparison with the uninfected controls; the number of larvae found in the brains of infected mice of the above-mentioned strains were lower than those detected in the BALB strain. There is no evidence that mechanical damage caused by migrating larvae in the brain tissue is mainly responsible for symptoms of central nervous toxocariasis. Likewise, the assumption that the MHC is involved in the allergic-inflammatory response in the brain could not be proven: infected mice of the BALB and DBA strains reacted completely differently, although both are equipped with the same MHC haplotype.
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