ArticleThe EMBO journal1995
Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- SUMO1-regulated DBC1 promotes p53-dependent stress-induced apoptosis of lens epithelial cells.Aging · 2023Article
- Review
- The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Profiling of chromatin accessibility and identification of general cis-regulatory mechanisms that control two ocular lens differentiation pathways.Epigenetics & chromatin · 2019Article
- c-Myc regulates cell proliferation during lens development.PloS one · 2014Article
- Identification and characterization of FGF2-dependent mRNA: microRNA networks during lens fiber cell differentiation.G3 (Bethesda, Md.) · 2013Article
- Early fetal hypoxia leads to growth restriction and myocardial thinning.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
- Apoptosis and differentiation of human embryonic stem cells induced by sustained activation of c-Myc.Oncogene · 2007Article
- ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory.Molecular and cellular biology · 2004Article
- Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas.The American journal of pathology · 2003Article
- Elevated proto-oncogene and collagen mRNA expression in PVR retinas.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2003Article
- alpha4beta1 integrin regulates lamellipodia protrusion via a focal complex/focal adhesion-independent mechanism.Molecular biology of the cell · 2002Article
- Modulation of c-myc, max, and mad gene expression during neural differentiation of embryonic stem cells by all-trans-retinoic acid.Gene expression · 2002Article
- N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation.Genes & development · 2000Article
- Disruption of retinoblastoma protein family function by human papillomavirus type 16 E7 oncoprotein inhibits lens development in part through E2F-1.Molecular and cellular biology · 1999Article
- MYC oncogenes and human neoplastic disease.Oncogene · 1999Review
- Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo.Molecular and cellular biology · 1999Article
- Dystrophic muscle in mice chimeric for expression of alpha5 integrin.The Journal of cell biology · 1998Article
- Expression and activity of L-Myc in normal mouse development.Molecular and cellular biology · 1996Article
- Lens complementation system for the genetic analysis of growth, differentiation, and apoptosis in vivo.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Although myc family genes are differentially expressed during development, their expression frequently overlaps, suggesting that they may serve both distinct and common biological functions. In addition, alterations in their expression occur at major developmental transitions in many cell lineages. For example, during mouse lens maturation, the growth arrest and differentiation of epithelial cells into lens fiber cells is associated with a decrease in L- and c-myc expression and a reciprocal rise in N-myc levels. To determine whether the down-regulation of L- and c-myc are required for mitotic arrest and/or completion of differentiation and whether these genes have distinct or similar activities in the same cell type, we have studied the consequences of forced L- and c-myc expression in the lens fiber cell compartment using the alpha A-crystallin promoter in transgenic mice (alpha A/L-myc and alpha A/c-myc mice). With respect to morphological and molecular differentiation, alpha A/L-myc lenses were characterized by a severely disorganized lens fiber cell compartment and a significant decrease in the expression of a late-stage differentiation marker (MIP26); in contrast, differentiation appeared to be unaffected in alpha A/c-myc mice. Furthermore, an analysis of proliferation indicated that while alpha A/L-myc fiber cells withdrew properly from the cell cycle, inappropriate cell cycle progression occurred in the lens fiber cell compartment of alpha A/c-myc mice. These observations indicate that continued late-stage expression of L-myc affected differentiation processes directly, rather than indirectly through deregulated growth control, whereas constitutive c-myc expression inhibited proliferative arrest, but did not appear to disturb differentiation. As a direct corollary, our data indicate that L-Myc and c-Myc are involved in distinct physiological processes in the same cell type.
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Registered trials
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