ArticleThe EMBO journal1995
Ecdysone regulation of the Drosophila Sgs-4 gene is mediated by the synergistic action of ecdysone receptor and SEBP 3.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 67 citations in OpenAlex.
- The Drosophila larval salivary gland, a simple and elegant model system to understand secretory organ development and function.Current opinion in insect science · 2026Review
- Anatomy and evolution of a DNA replication origin.Chromosoma · 2021Article
- Hormonal activation of let-7-C microRNAs via EcR is required for adult Drosophila melanogaster morphology and function.Development (Cambridge, England) · 2012Article
- Two adjacent cis-regulatory elements are required for ecdysone response of ecdysone receptor (EcR) B1 transcription.PloS one · 2012Article
- Drosophila suppressor of sable protein [Su(s)] promotes degradation of aberrant and transposon-derived RNAs.Molecular and cellular biology · 2009Article
- Umbrea, a chromo shadow domain protein in Drosophila melanogaster heterochromatin, interacts with Hip, HP1 and HOAP.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
- A novel ecdysone receptor mediates steroid-regulated developmental events during the mid-third instar of Drosophila.PLoS genetics · 2008Article
- Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Ecdysone receptor expression in developing and adult mushroom bodies of the ant Camponotus japonicus.Development genes and evolution · 2007Article
- Synergistic action of E74B and ecdysteroid receptor in activating a 20-hydroxyecdysone effector gene.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Structure of the heterodimeric ecdysone receptor DNA-binding complex.The EMBO journal · 2003Article
- Chromosomal localization links the SIN3-RPD3 complex to the regulation of chromatin condensation, histone acetylation and gene expression.The EMBO journal · 2000Article
- Genomic structure and ecdysone regulation of the prophenoloxidase 1 gene in the malaria vector Anopheles gambiae.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Structure and regulation of the salivary gland secretion protein gene Sgs-1 of Drosophila melanogaster.Genetics · 1999Article
- The fork head product directly specifies the tissue-specific hormone responsiveness of the Drosophila Sgs-4 gene.The EMBO journal · 1996Article
- The Drosophila fork head factor directly controls larval salivary gland-specific expression of the glue protein gene Sgs3.Nucleic acids research · 1996Article
- Direct repeats bind the EcR/USP receptor and mediate ecdysteroid responses in Drosophila melanogaster.Molecular and cellular biology · 1996Article
- Characterization of an EcR/USP heterodimer target site that mediates ecdysone responsiveness of the Drosophila Lsp-2 gene.Molecular & general genetics : MGG · 1995Article
- Building and specializing epithelial tubular organs: the Drosophila salivary gland as a model system for revealing how epithelial organs are specified, form and specialize.Wiley interdisciplinary reviews. Developmental biologyReview
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The steroid hormone 20-hydroxyecdysone controls both induction and repression of the Drosophila 'intermolt gene' Sgs-4. We show here that the ecdysone receptor binds to two sites, element I and element II, in the regulatory region of Sgs-4. A functional analysis revealed that element II appears to be of no importance for Sgs-4 expression, while element I proved to be an ecdysone response element that is necessary, but not sufficient, for induction of Sgs-4 expression. Our results provide no evidence that repression of Sgs-4 expression is mediated by one of the two receptor binding sites. In the close vicinity of elements I and II, we detected two binding sites of secretion enhancer binding protein 3 (SEBP 3). Like receptor element I, one of these sites also proved to be necessary, but not sufficient, for expression of Sgs-4. Therefore, induction of Sgs-4 requires binding of both ecdysone receptor and SEBP 3 to a complex hormone response unit, which also contains binding sites for a third factor, SEBP 2. The SEBP 2 sites coincide with binding sites of products of the Broad-Complex locus, which has been implicated recently with transduction of the hormonal signal. Thus, the available data suggest that induction of Sgs-4, and possibly other 'intermolt genes', is a combination of a primary and a secondary response to the hormone.
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