ReviewBreast cancer research and treatment1994
Matrix-degrading proteases in hormone-dependent breast cancer.
Review in Breast cancer research and treatment, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 11 citations in OpenAlex.
- Transcriptional repression of the human collagenase-1 (MMP-1) gene in MDA231 breast cancer cells by all-trans-retinoic acid requires distal regions of the promoter.British journal of cancer · 1999Article
- Regulation of tissue-degrading factors and in vitro invasiveness in progression of breast cancer cells.Clinical & experimental metastasis · 1998Article
- The location of acidic fibroblast growth factor in the breast is dependent on the activity of proteases present in breast cancer tissue.British journal of cancer · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteases have emerged as important modulators of the metastatic capacity of cancer. However, metastasis is regulated by multiple other characteristics of the tumor cell and evidence suggests the participation of multiple classes of proteases. In the present article we review the literature concerning the potential biological roles of multiple proteases in breast cancer. In particular, we focus on the gelatin-degrading metallo proteinase and on a novel 80 KDa matrix-degrading protease that appears to be commonly expressed in hormone dependent breast cancer cell lines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.