ArticleProceedings of the National Academy of Sciences of the United States of America1995
Differential expression of mRNAs for protein kinase inhibitor isoforms in mouse brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 20 citations in OpenAlex.
- Protein Kinase A as a Promising Target for Heart Failure Drug Development.Archives of medical research · 2018Review
- Reproductive function in protein kinase inhibitor-deficient mice.Molecular and cellular biology · 2001Article
- Deficient gene expression in protein kinase inhibitor alpha Null mutant mice.Molecular and cellular biology · 2000Article
- The mouse Prkacn2 gene encoding protein kinase A inhibitor 2 is located on proximal chromosome 10.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Many neurotransmitters are known to regulate neuronal cell function by means of activation of cAMP-dependent protein kinase (PKA) and phosphorylation of neuronal substrate proteins, including transcription factors and ion channels. Here, we have characterized the gene expression of two isoforms of a protein kinase inhibitor (PKI) specific for PKA in mouse brain by RNase protection and in situ hybridization histochemistry. The studies demonstrate that the PKI alpha isoform is abundant in many regions of the adult mouse brain but particularly in cerebellum, hypothalamus, hippocampus, and cortex. In contrast, PKI beta is present at much lower levels in most brain regions but is found in significant amounts in the cerebellum, as well as in distinct nuclei within the pons, medulla, and hypothalamus. These results are consistent with a regulatory role of endogenous PKI in PKA-mediated signal transduction in brain and suggest differential functions for the two isoforms of PKI within the central nervous system.
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