ArticleProceedings of the National Academy of Sciences of the United States of America1995
Functional identification of the promoter for the gene encoding the alpha subunit of calcium/calmodulin-dependent protein kinase II.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 23 citations in OpenAlex.
- Functional implications of CaMKII alternative splicing.The European journal of neuroscience · 2021Review
- Activity-regulated genes as mediators of neural circuit plasticity.Progress in neurobiology · 2011Review
- Neuronal PPARgamma deficiency increases susceptibility to brain damage after cerebral ischemia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Identification of the RA response element and transcriptional silencer in human alphaCaMKII promoter.Molecular biology reports · 2008Article
- Retinoic acid stimulates alpha-CAMKII gene expression in PC12 cells at a distinct transcription initiation site.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To examine the expression of the alpha subunit of calcium/calmodulin-dependent protein kinase II, various 5' flanking genomic sequences were inserted into a chloramphenicol acetyltransferase (CAT) reporter plasmid and CAT enzyme activities were analyzed in transfected NB2a neuroblastoma cells and mRNA transcription was analyzed by nuclease protection assays. A core promoter was identified which contained an essential TATA element located 162 nt 5' to the transcription start site. Sequences 3' to the transcription start site, as well as 5' to the TATA element, increased levels of CAT activity in transfected cells. The alpha-subunit gene promoter displayed higher CAT activities, relative to a simian virus 40 promoter, in transfected neuronal cell lines than in nonneuronal cell lines. Results also suggested that sequence surrounding the natural alpha-gene transcription initiation site may be important for targeting transcription initiation 162 nt downstream of its TATA element.
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