ArticleProceedings of the National Academy of Sciences of the United States of America1995
Expression of a human alpha-1,3/4-fucosyltransferase in the pit cell lineage of FVB/N mouse stomach results in production of Leb-containing glycoconjugates: a potential transgenic mouse model for studying Helicobacter pylori infection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 133 citations in OpenAlex.
- Managing dangerous liaisons: lessons fromJournal of bacteriology · 2026Review
- Ferric quinate (QPLEX) inhibits the interaction of major outer membrane protein (MOMP) with the Lewis b (LeFrontiers in microbiology · 2023Article
- Enhanced Fitness of a Helicobacter pyloriInfection and immunity · 2021Article
- Review
- The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice.Science (New York, N.Y.) · 2019Article
- Host Determinants of Expression of the Helicobacter pylori BabA Adhesin.Scientific reports · 2017Article
- Glycan Specificity of P[19] Rotavirus and Comparison with Those of Related P Genotypes.Journal of virology · 2016Article
- Muc5ac gastric mucin glycosylation is shaped by FUT2 activity and functionally impacts Helicobacter pylori binding.Scientific reports · 2016Article
- Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori.Cell host & microbe · 2016Article
- A repetitive DNA element regulates expression of the Helicobacter pylori sialic acid binding adhesin by a rheostat-like mechanism.PLoS pathogens · 2014Article
- The genetics of complex cholestatic disorders.Gastroenterology · 2013Review
- Chronic Helicobacter pylori infection and DNA-damaged stem cells: a recipe for disaster.Digestive diseases and sciences · 2013Article
- BabA-mediated adherence is a potentiator of the Helicobacter pylori type IV secretion system activity.The Journal of biological chemistry · 2011Article
- Role of innate immunity in Helicobacter pylori-induced gastric malignancy.Physiological reviews · 2010Review
- Helicobacter pylori: gastric cancer and beyond.Nature reviews. Cancer · 2010Review
- Host-dependent Lewis (Le) antigen expression in Helicobacter pylori cells recovered from Leb-transgenic mice.The Journal of experimental medicine · 2009Article
- Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosa.Glycobiology · 2009Article
- Roles of Helicobacter pylori BabA in gastroduodenal pathogenesis.World journal of gastroenterology · 2008Review
- Lipopolysaccharide diversity evolving in Helicobacter pylori communities through genetic modifications in fucosyltransferases.PloS one · 2008Article
- Host Lewis phenotype-dependent Helicobacter pylori Lewis antigen expression in rhesus monkeys.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Helicobacter pylori is a human pathogen associated with the development of gastric and duodenal ulcers and gastric adenocarcinoma. To test the hypothesis that the human Lewis(b) blood group antigen (Le(b)) functions as a receptor for the bacteria's adhesins and mediates its attachment to gastric pit and surface mucous cells, a human alpha-1,3/4-fucosyltransferase was expressed in these cell lineages in FVB/N transgenic mice. The fucosyltransferase directed production of the Leb epitope without any apparent effect on the proliferation and differentiation programs of this lineage. Moreover, clinical isolates of H. pylori bound to these cells in transgenic mice but not in their normal littermates. Binding was blocked by pretreatment of the bacteria with soluble Le(b). This mouse model could be useful for examining the molecular pathogenesis of diseases caused by H. pylori infection. Creating novel pathways for production of specific oligosaccharides in selected cell lineages of transgenic animals represents an approach for examining the role of complex carbohydrates in regulating cellular differentiation and host-microbe interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.