ArticleProceedings of the National Academy of Sciences of the United States of America1995
A diabetes-associated T-cell autoantigen maps to a telomeric locus on mouse chromosome 6.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Hybrid Insulin Peptides as Antigens and Tolerogens for Pathogenic T Cells in Autoimmune Diabetes.Immunological reviews · 2026Review
- Islet amyloid disrupts MHC class II antigen presentation and delays autoimmune diabetes in NOD mice.Diabetologia · 2026Article
- Antigen-specific T cell responses in autoimmune diabetes.Frontiers in immunology · 2024Review
- Lysosomal cathepsin creates chimeric epitopes for diabetogenic CD4 T cells via transpeptidation.The Journal of experimental medicine · 2021Article
- Hidden in Plain View: Discovery of Chimeric Diabetogenic CD4 T Cell Neo-Epitopes.Frontiers in immunology · 2021Review
- Identification of Hybrid Insulin Peptides (HIPs) in Mouse and Human Islets by Mass Spectrometry.Journal of proteome research · 2019Article
- Islet encapsulation with polyphenol coatings decreases pro-inflammatory chemokine synthesis and T cell trafficking.Biomaterials · 2017Article
- An insulin-IAPP hybrid peptide is an endogenous antigen for CD4 T cells in the non-obese diabetic mouse.Journal of autoimmunity · 2017Article
- Antigen recognition in the islets changes with progression of autoimmune islet infiltration.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- An alternative role for Foxp3 as an effector T cell regulator controlled through CD40.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Novel autoantigens for diabetogenic CD4 T cells in autoimmune diabetes.Immunologic research · 2013Review
- Article
- Mapping of the murine type 1 diabetes locus Idd20 by genetic interaction.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- T-cell epitopes in type 1 diabetes.Current diabetes reports · 2004Review
- Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Evidence for the presence of insulin-dependent diabetes-associated alleles on the distal part of mouse chromosome 6.Genome research · 1998Article
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Authors and funding
3 authors.
Funding
Abstract
Identification of diabetes-associated T-cell autoantigens is important for understanding the immunopathology of diabetes and developing improved therapeutic strategies. We have used a genetic approach to move toward identifying the autoantigen recognized by a diabetogenic islet-specific T-cell clone from a nonobese diabetic (NOD) mouse. The unique antigen recognition pattern of this clone was utilized to map the gene encoding the antigen (or its expression) by genetic linkage analysis. In vitro analysis of T-cell proliferation by this clone showed that the capacity of the islets to stimulate T cells segregates as a single codominant gene in BALB/cByJ x (BALB/cByJ x NOD/Bdc) backcross mice. This phenotype was tightly linked to two microsatellites in the telomeric region of mouse chromosome 6.
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