Evidence map›Paper›PMID 7876303›Full record

ArticleThe Journal of cell biology1995

Chromokinesin: a DNA-binding, kinesin-like nuclear protein.

S Z Wang, R Adler

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 134 citations in OpenAlex.

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  16. Regulation of chromosome speeds in mitosis.Cellular and molecular bioengineering · 2013
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

S Z WangRetinal Degenerations Research Center, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-9257.
R Adler
Johns Hopkins University · US

Funding

Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI Jiang Qian · 1985 to 2026
$22.1M
VISUAL NEURONS: DEVELOPMENT AND REGENERATION IN VITROR01EY004859 · NEI · JOHNS HOPKINS UNIVERSITY · PI CANTO-SOLER, MARIA VALERIA · 1985 to 2010
$6.2M
NEI NIH HHS EY01765NEI NIH HHS EY04859
6 · The paper itself

Abstract

Microtubule-associated mechanoenzymes have been proposed to play a fundamental role in chromosome movement. We have cloned and characterized the cDNA for a novel protein, named Chromokinesin, that fulfills several of the criteria expected of a mitotic motor. Chromokinesin contains both a kinesin motor-like domain and an unusual basic-leucine zipper DNA-binding domain. Its mRNA is readily detectable in proliferating cells, but not in postmitotic cells. Immunocytochemical analysis with antibodies directed against the nonconserved COOH-terminal region of Chromokinesin indicates that the protein is localized in the nucleus, and primarily associated with chromosome arms in mitotic cells. These data suggest that Chromokinesin is likely to function as a microtubule-based mitotic motor with DNA as its cargo.

Indexed as

Amino Acid SequenceAnimalsBase SequenceCell DivisionChick EmbryoChromosomesCloning, MolecularDNA-Binding ProteinsEscherichia coliImmunohistochemistryIn Situ HybridizationKinesinsLeucine ZippersMitosisMolecular Sequence DataNuclear ProteinschromokinesinDNA-Binding ProteinsKinesinsNuclear ProteinsRecombinant Fusion Proteins

Identifiers

PMID7876303
PMCPMC2120390
OpenAlexW2166434216

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.