ArticleThe Journal of cell biology1995
CEP3 encodes a centromere protein of Saccharomyces cerevisiae.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 80 citations in OpenAlex.
- Native yeast kinetochore structures identify an essential inner kinetochore interaction.Nature communications · 2026Article
- Native yeast kinetochore structures identify an essential inner kinetochore interaction.bioRxiv : the preprint server for biology · 2026Article
- Some illuminating remarks on molecular genetics and genomics as well as drug development.Molecular genetics and genomics : MGG · 2020Review
- Cell cycle-dependent association of polo kinase Cdc5 with CENP-A contributes to faithful chromosome segregation in budding yeast.Molecular biology of the cell · 2019Article
- Structural basis for assembly of the CBF3 kinetochore complex.The EMBO journal · 2018Article
- Structural integrity of centromeric chromatin and faithful chromosome segregation requires Pat1.Genetics · 2013Article
- Review
- Novel checkpoint pathway organization promotes genome stability in stationary-phase yeast cells.Molecular and cellular biology · 2013Article
- Ndc10 is a platform for inner kinetochore assembly in budding yeast.Nature structural & molecular biology · 2011Article
- Sgt1 dimerization is negatively regulated by protein kinase CK2-mediated phosphorylation at Ser361.The Journal of biological chemistry · 2009Article
- Sgt1 dimerization is required for yeast kinetochore assembly.The Journal of biological chemistry · 2009Article
- Structural and functional dissection of Mif2p, a conserved DNA-binding kinetochore protein.Molecular biology of the cell · 2008Article
- Insights into kinetochore-DNA interactions from the structure of Cep3Delta.EMBO reports · 2008Article
- A fungal family of transcriptional regulators: the zinc cluster proteins.Microbiology and molecular biology reviews : MMBR · 2006Review
- 17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation.Oncogene · 2006Article
- Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Sgt1 associates with Hsp90: an initial step of assembly of the core kinetochore complex.Molecular and cellular biology · 2004Article
- Sgt1p and Skp1p modulate the assembly and turnover of CBF3 complexes required for proper kinetochore function.Molecular biology of the cell · 2004Article
- Genetic interactions between an RNA polymerase II phosphatase and centromeric elements in Saccharomyces cerevisiae.Molecular genetics and genomics : MGG · 2004Article
- Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast.The Journal of cell biology · 2004Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We have designed a screen to identify mutants specifically affecting kinetochore function in the yeast Saccharomyces cerevisiae. The selection procedure was based on the generation of "synthetic acentric" minichromosomes. "Synthetic acentric" minichromosomes contain a centromere locus, but lack centromere activity due to combination of mutations in centromere DNA and in a chromosomal gene (CEP) encoding a putative centromere protein. Ten conditional lethal cep mutants were isolated, seven were found to be alleles of NDC10 (CEP2) encoding the 110-kD protein of yeast kinetochore. Three mutants defined a novel essential gene CEP3. The CEP3 product (Cep3p) is a 71-kD protein with a potential DNA-binding domain (binuclear Zn-cluster). At nonpermissive temperature the cep3 cells arrest with an undivided nucleus and a short mitotic spindle. At permissive temperature the cep3 cells are unable to support segregation of minichromosomes with mutations in the central part of element III of yeast centromere DNA. These minichromosomes, when isolated from cep3 cultures, fail to bind bovine microtubules in vitro. The sum of genetic, cytological and biochemical data lead us to suggest that the Cep3 protein is a DNA-binding component of yeast centromere. Molecular mass and sequence comparison confirm that Cep3p is the p64 component of centromere DNA binding complex Cbf3 (Lechner, 1994).
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