Evidence map›Paper›PMID 7873875›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society1994

The stumbler mutation maps to proximal mouse chromosome 2.

W N Frankel, H O Sweet, M T Davisson

Abstract read
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In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. New seizure frequency QTL and the complex genetics of epilepsy in EL mice.Mammalian genome : official journal of the International Mammalian Genome Society · 1995
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

W N FrankelJackson Laboratory, Bar Harbor, Maine 04609.
H O Sweet
M T Davisson

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9M
GENETIC DETERMINANTS OF EPILEPSY IN MURINE SYSTEMSR01NS031348 · NINDS · JACKSON LABORATORY · PI SANDS, TRISTAN T · 1993 to 2025
$11.5M
NEURAL TUBE DEFECTS IN CURLY TAIL MICE--GENES &EMBRYOSU01HD028882 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI BERNFIELD, MERTON R · 1992 to 1996
–
NCI NIH HHS CA 34196NICHD NIH HHS U01HD28882NINDS NIH HHS R01NS31348
6 · The paper itself

Abstract

The cerebellar mouse mutation stumbler (stu) was mapped to proximal Chromosome (Chr) 2 with a recently developed polymerase chain reaction assay for endogenous retroviruses that vary between mouse strains. The stu locus resides between the markers D2Mit5 and D2Mit7. A number of developmentally or neurologically relevant candidate genes map in this region, including Bmi1, Dbh, Grin1, Notch1, Pax8, Rxra, and Spna2. Knowing the chromosomal localization of stu should simplify maintenance of the stumbler mouse stock and also enable analysis of the cerebellar defect in presymptomatic individuals.

Indexed as

Chromosome MappingMutationAnimalsBase SequenceCerebellar AtaxiaCrosses, GeneticFemaleGenetic MarkersMaleMiceMice, Inbred C3HMice, Inbred C57BLMice, Neurologic MutantsMolecular Sequence DataPolymerase Chain ReactionGenetic Markers

Identifiers

PMID7873875

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.