ArticleNucleic acids research1995
Ubiquitous mammalian-wide interspersed repeats (MIRs) are molecular fossils from the mesozoic era.
Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Genomic sequence evolution underlying human neocortical interareal diversification.Genome biology · 2026Article
- Selection for Molecularly Complementary Modules (MCMs) Drives the Origins and Evolution of Pleiofunctional, Epistatic Interactomes (PEIs).Life (Basel, Switzerland) · 2026Review
- TAD evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function.Nature communications · 2023Article
- Comparative analysis of transposable elements provides insights into genome evolution in the genus Camelus.BMC genomics · 2021Article
- Retrotransposons as Drivers of Mammalian Brain Evolution.Life (Basel, Switzerland) · 2021Review
- Biosynthesis of Circular RNA ciRS-7/CDR1as Is Mediated by Mammalian-wide Interspersed Repeats.iScience · 2020Article
- Ancient exapted transposable elements promote nuclear enrichment of human long noncoding RNAs.Genome research · 2019Article
- MIR sequences recruit zinc finger protein ZNF768 to expressed genes.Nucleic acids research · 2019Article
- Review
- Transposable elements in cancer.Nature reviews. Cancer · 2017Review
- Identification of RNA Polymerase III-Transcribed SINEs at Single-Locus Resolution from RNA Sequencing Data.Non-coding RNA · 2017Review
- Whole-genome expression analysis of mammalian-wide interspersed repeat elements in human cell lines.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017Article
- MIR retrotransposon sequences provide insulators to the human genome.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Evolutionary histories of transposable elements in the genome of the largest living marsupial carnivore, the Tasmanian devil.Molecular biology and evolution · 2015Article
- Mammalian-wide interspersed repeat (MIR)-derived enhancers and the regulation of human gene expression.Mobile DNA · 2014Article
- Identification of an ancient endogenous retrovirus, predating the divergence of the placental mammals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
- RNA-Mediated Gene Duplication and Retroposons: Retrogenes, LINEs, SINEs, and Sequence Specificity.International journal of evolutionary biology · 2013Article
- The role of Transposable Elements in shaping the combinatorial interaction of Transcription Factors.BMC genomics · 2012Article
- Genome-wide DNA methylation analyses in the brain reveal four differentially methylated regions between humans and non-human primates.BMC evolutionary biology · 2012Article
- Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict.Cell · 2012Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Short interspersed elements (SINEs) are ubiquitous in mammalian genomes. Remarkable variety of these repeats among placental orders indicates that most of them amplified in each lineage independently, following mammalian radiation. Here, we present an ancient family of repeats, whose sequence divergence and common occurrence among placental mammals, marsupials and monotremes indicate their amplification during the Mesozoic era. They are called MIRs for abundant Mammalian-wide Interspersed Repeats. With approximately 120,000 copies still detectable in the human genome (0.2-0.3% DNA), MIRs represent a 'fossilized' record of a major genetic event preceding the radiation of placental orders.
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