ArticleThe Journal of physiology1994
Selective potentiation of a novel calcium channel in rat hippocampal neurones.
Article in The Journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels.The Journal of general physiology · 2023Article
- Rapid homeostatic plasticity and neuropsychiatric therapeutics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- The Molecular Basis for the Calcium-Dependent Slow Afterhyperpolarization in CA1 Hippocampal Pyramidal Neurons.Frontiers in physiology · 2021Review
- Calcium dependence of spontaneous neurotransmitter release.Journal of neuroscience research · 2018Review
- Activity-Dependent Facilitation of CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Small-conductance Ca2+-activated K+ channels modulate action potential-induced Ca2+ transients in hippocampal neurons.Journal of neurophysiology · 2013Article
- Ca²⁺-dependent regulation of Ca²⁺ currents in rat primary afferent neurons: role of CaMKII and the effect of injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Neurotoxicity following acute inhalation exposure to the oil dispersant COREXIT EC9500A.Journal of toxicology and environmental health. Part A · 2011Article
- CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation-transcription coupling.The Journal of cell biology · 2008Article
- Bayesian estimation of synaptic physiology from the spectral responses of neural masses.NeuroImage · 2008Article
- Molecular nature of anomalous L-type calcium channels in mouse cerebellar granule cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- AII amacrine cells express L-type calcium channels at their output synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Protein kinase C is involved in M1-muscarinic receptor-mediated facilitation of L-type Ca2+ channels in neurons of the major pelvic ganglion of the adult male rat.Neurochemical research · 2001Article
- Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Sustained activation of hippocampal Lp-type voltage-gated calcium channels by tetanic stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Decreased G-protein-mediated regulation and shift in calcium channel types with age in hippocampal cultures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Somatic amplification of distally generated subthreshold EPSPs in rat hippocampal pyramidal neurones.The Journal of physiology · 1999Article
- Anomalous L-type calcium channels of rat spinal motoneurons.The Journal of general physiology · 1999Article
- Beta-adrenergic stimulation selectively inhibits long-lasting L-type calcium channel facilitation in hippocampal pyramidal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Calcium channel activity in cultured embryonic hippocampal neurones was studied with the cell-attached configuration of the patch clamp technique. Single-channel recordings revealed the presence of a novel kind of calcium channel activity characterized by marked bursts of re-openings following voltage pulses to +20 mV from a holding potential of -40 mV. 2. The re-openings were greatly prolonged by the dihydropyridine (DHP) agonist (+)-(S)-202-791, thus ruling out the possibility that they arose from T-, N- or P-type channels. Furthermore, the novel gating pattern could be readily distinguished from that of the L-type channel which showed only conventional tail currents. 3. Since the novel gating pattern was stable over many minutes, we provisionally referred to it as a novel kind of calcium channel that showed voltage-dependent potentiation (Lp channel) to distinguish it from the 'standard' L-type channel (Ls channel). 4. Lp channels could also be distinguished from Ls channels on the basis of slope conductance (24.3 vs. 26.9 pS for Lp and Ls, respectively) and mean DHP-induced long open time (2.7 vs 11 ms at +20 mV for Lp and Ls, respectively). 5. Voltage-dependent potentiation of Lp channel activity was studied using a dual-pulse protocol. When preceded by conditioning prepulses, Lp responses to test pulses were greatly increased. Ls- and N-type calcium channels showed no such enhancement of their activity. 6. Long-duration recordings revealed no clear evidence for transitions from Ls to Lp gating (or vice versa), suggesting that Ls and Lp activities arose from different kinds of calcium channels or that Lp gating is an unusually long-lived mode of Ls channel gating.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.