ArticleThe Journal of experimental medicine1995
Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung.
Article in The Journal of experimental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 204 citations in OpenAlex.
- Kinetics of eotaxin expression and its relationship to eosinophil accumulation and activation in bronchial biopsies and bronchoalveolar lavage (BAL) of asthmatic patients after allergen inhalation.Clinical and experimental immunology · 1998Trial
- A current review on animal models of anti-asthmatic drugs screening.Frontiers in pharmacology · 2025Review
- Role of Eosinophils in Intestinal Inflammation and Fibrosis in Inflammatory Bowel Disease: An Overlooked Villain?Frontiers in immunology · 2021Review
- Food protein-induced allergic proctocolitis in infants: Literature review and proposal of a management protocol.The World Allergy Organization journal · 2020Review
- Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program.Blood · 2019Article
- Development of a Fully Cross-Validated Bayesian Network Approach for Local Control Prediction in Lung Cancer.IEEE transactions on radiation and plasma medical sciences · 2019Article
- Myeloid Cells in Asthma.Microbiology spectrum · 2017Review
- Interleukin-13 in Asthma and Other Eosinophilic Disorders.Frontiers in medicine · 2017Article
- Elements Involved In Promoting Eosinophilic Gastrointestinal Disorders.Journal of genetic syndromes & gene therapy · 2015Article
- Inhibition by new glucocorticoid antedrugs [16α, 17α-d] isoxazoline and [16α, 17α-d]-3'-hydroxy-iminoformyl isoxazoline derivatives of chemotaxis and CCL26, CCL11, IL-8, and RANTES secretion.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2013Article
- Colonic eosinophilic inflammation in experimental colitis is mediated by Ly6C(high) CCR2(+) inflammatory monocyte/macrophage-derived CCL11.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Role of eotaxin-1 signaling in ovarian cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
- Chemotactic factors associated with eosinophilic gastrointestinal diseases.Immunology and allergy clinics of North America · 2009Review
- IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity.The Journal of experimental medicine · 2008Article
- Eosinophilic gastroenteritis: a review.Journal of gastroenterology · 2008Review
- Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility.The Journal of allergy and clinical immunology · 2006Article
- Eosinophil function in allergic inflammation: from bone marrow to tissue response.Current allergy and asthma reports · 2004Review
- Mechanisms of eosinophil recruitment and activation.Current allergy and asthma reports · 2002Review
- Chemokines in allergic lung inflammation.Immunology · 2002Review
- Eotaxin and the attraction of eosinophils to the asthmatic lung.Respiratory research · 2001Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eotaxin is a member of the C-C family of chemokines and is related during antigen challenge in a guinea pig model of allergic airway inflammation (asthma). Consistent with its putative role in eosinophilic inflammation, eotaxin induces the selective infiltration of eosinophils when injected into the lung and skin. Using a guinea pig lung cDNA library, we have cloned full-length eotaxin cDNA. The cDNA encodes a protein of 96 amino acids, including a putative 23-amino acid hydrophobic leader sequence, followed by 73 amino acids composing the mature active eotaxin protein. The protein-coding region of this cDNA is 73, 71, 50, and 48% identical in nucleic acid sequence to those of human macrophage chemoattractant protein (MCP) 3, MCP-1, macrophage inflammatory protein (MIP) 1 alpha, and RANTES, respectively. Analysis of genomic DNA suggested that there is a single eotaxin gene in guinea pig which is apparently conserved in mice. High constitutive levels of eotaxin mRNA expression were observed in the lung, while the intestines, stomach, spleen, liver, heart, thymus, testes, and kidney expressed lower levels. To determine if eotaxin mRNA levels are elevated during allergen-induced eosinophilic airway inflammation, ovalbumin (OVA)-sensitized guinea pigs were challenged with aerosolized antigen. Compared with the lungs from saline-challenged animals, eotaxin mRNA levels increased sixfold within 3 h and returned to baseline by 6 h. Thus, eotaxin mRNA levels are increased in response to allergen challenge during the late phase response. The identification of constitutive eotaxin mRNA expression in multiple tissues suggests that in addition to regulating airway eosinophilia, eotaxin is likely to be involved in eosinophil recruitment into other tissues as well as in baseline tissue homing.
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